Induction of the Chlamydia muridarum stress/persistence response increases azithromycin treatment failure in a murine model of infection

Antimicrobial Agents and Chemotherapy
R Phillips-CampbellR V Schoborg

Abstract

Viable but noninfectious (stressed/persistent) chlamydiae are more resistant to azithromycin (AZM) in culture than are organisms in the normal developmental cycle. Chlamydia muridarum-infected mice were exposed to amoxicillin to induce the organisms to enter the persistent/stressed state and subsequently treated with AZM. AZM treatment failure was observed in 22% of persistently infected mice, with an average of 321,667 inclusion-forming units (IFU) shed after AZM treatment. Productively infected mice had a 9% rate of AZM treatment failure and shed an average of 12,083 IFU. These data suggest that stressed chlamydiaeare more resistant to frontline antichlamydial drugs in vivo.

Citations

Dec 7, 2014·The Journal of Antimicrobial Chemotherapy·Jane S HockingSepehr N Tabrizi
May 25, 2016·Current Clinical Microbiology Reports·Nicole BorelRobert V Schoborg
Mar 22, 2016·International Journal of Microbiology·Cory Ann LeonardNicole Borel
Feb 1, 2015·The Journal of Antimicrobial Chemotherapy·Fabian Yuh Shiong KongJane S Hocking
Jul 30, 2015·BMC Infectious Diseases·Fabian Yuh Shiong Kong, Jane Simone Hocking
Jun 25, 2014·Frontiers in Cellular and Infection Microbiology·Kyla M FrohlichLi Shen
Oct 26, 2018·Frontiers in Aging Neuroscience·Brian J BalinAlan P Hudson
Jan 9, 2019·Frontiers in Microbiology·Maria Emilia PanzettaHector Alex Saka
Apr 11, 2018·Pathogens and Disease·Ildikó LantosValéria Endrész

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