Induction of the imbalance of helper T-cell functions in mice exposed to diesel exhaust

The Science of the Total Environment
H FujimakiN Ui

Abstract

Administration of diesel exhaust particles (DEP) increases antigen-specific IgE production and IgE-secreting cells, and induces Th2-type cytokine profiles in the airway in mice and humans. To determine the early effects of diesel exhaust (DE) inhalation on the cytokine production profile, BALB/c mice were exposed to 0 (controls) and 1.0 mg/m3 DE inhalation for 4 weeks. Intraperitoneal sensitization with ovalbumin (OVA) was conducted immediately before DE inhalation. Mice were treated with anti-CD4 or anti-CD8 mAb 1 day before and after the sensitization. On day 21, these mice were boosted with OVA and blood; bronchoalveolar lavage (BAL) fluid, and spleens were collected on day 28. In BAL fluid, both TNFalpha and IL-10 production in DE-exposed and control mice remained basically the same. IL-6 production in the anti-CD4 treatment group of DE-exposed mice, however, significantly increased compared with that of the controls. In vitro antigen-stimulated interleukin-4 (IL-4) and -10 (IL-10) production in spleen cells of exposed mice were not affected by low-dose DE inhalation. In vitro interferon (IFN)-gamma production in the anti-CD4 treated group of exposed mice decreased markedly. Although anti-OVA IgE production in the plasma of...Continue Reading

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Citations

Jul 15, 2003·Journal of Toxicology and Environmental Health. Part a·P A SteerenbergF R Casee
Aug 27, 2002·Environmental Health Perspectives·George D Leikauf
Apr 5, 2005·Immunopharmacology and Immunotoxicology·Kazuyasu FujiiKeiji Iwatsuki
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Nov 7, 2013·Reviews on Environmental Health·Sushil KumarAnup K Srivastava
Mar 13, 2009·Critical Reviews in Toxicology·Thomas W HesterbergPeter A Valberg

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