Induction of the TRPM-2 gene in cells undergoing programmed death.

Molecular and Cellular Biology
R ButtyanI S Sawczuk

Abstract

RNA and protein products encoded by the testosterone-repressed prostate message-2 gene (TRPM-2) are induced to high levels, coordinate with the onset of cell death, in numerous rodent models of inducible tissue damage. These models include cell death initiated by hormonal stimuli (prostate regression), pressure insult (renal atrophy after ureteral obstruction), developmental stimuli (necrosis of interdigital tissue), and cytotoxic injury (chemotherapeutic regression of a tumor). Sequence analysis of cDNA encoding TRPM-2 revealed its close homology with a product referred to as SGP-2 or clusterin expressed constitutively by Sertoli cells; however, the immunologically related polypeptides expressed in regressing tissues differ in molecular mass from the forms secreted by the testis. Although the function(s) of the products encoded by the TRPM-2 gene remains unclear, their presence provides a remarkable and early indicator of programmed cell death in many types of mammalian cells.

References

Jan 1, 1975·Vitamins and Hormones·N BruchovskyS Craven
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1986·The Prostate·M L MontpetitM Tenniswood
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G L Mutter, D J Wolgemuth
Aug 31, 1987·Biochemical and Biophysical Research Communications·J G LégerM P Tenniswood
Nov 4, 1966·Science·J W Saunders
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R C DukeJ J Cohen
Jan 1, 1984·The Prostate·J T Isaacs
Apr 1, 1983·Kidney International·S J ZelmanB B Davis
Jan 1, 1983·Urological Research·W G WalshR deVere White
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Feb 1, 1951·Biological Reviews of the Cambridge Philosophical Society·A GLUCKSMANN

❮ Previous
Next ❯

Citations

Oct 4, 2006·Expert Opinion on Drug Metabolism & Toxicology·Vishal S Vaidya, Joseph V Bonventre
Nov 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D P WitteJ A Harmony
Jan 1, 1992·The European Journal of Neuroscience·M. C. SenutY. Lamour
Mar 1, 1996·The European Journal of Neuroscience·R ChiesaG Forloni
Mar 1, 1994·Chest·P B BittermanD H Ingbar
Jun 1, 1991·Kidney International·M E Rosenberg, M S Paller
Apr 1, 1992·Kidney International·R Correa-RotterM E Rosenberg
Mar 1, 1994·Kidney International·J R SaundersB F Murphy
Mar 1, 1994·Kidney International·J DvergstenM E Rosenberg
May 8, 1992·Brain Research·P L McGeerD G Walker
Apr 1, 1992·Toxicology and Applied Pharmacology·G B Corcoran, S D Ray
Mar 16, 2007·Biochemical and Biophysical Research Communications·Vuk SavkovićHans Bödeker
Sep 1, 1996·Neurobiology of Aging·N H Choi-Miura, T Oda
Aug 1, 1997·The Journal of Urology·L T KleinR Shabsigh
Mar 1, 1993·Trends in Endocrinology and Metabolism : TEM·I B Fritz, B Murphy
Aug 2, 2003·Biochemical and Biophysical Research Communications·Seishiro HiranoMegumi Yamamoto
Jun 15, 2000·Experimental Cell Research·I Zwain, P Amato
May 2, 2016·Experimental Eye Research·M Elizabeth FiniMark R Wilson
Jan 29, 2013·Annual Review of Biochemistry·Amy R WyattMark R Wilson
Jun 4, 2014·Animal Reproduction Science·J P A RegoM R McGowan
Aug 1, 1992·Biological Reviews of the Cambridge Philosophical Society·S Sen
Oct 1, 1991·American Journal of Reproductive Immunology : AJRI·I Leibovitch, R Buttyan
Sep 1, 1993·Arquivos de neuro-psiquiatria·A S OliveiraA P Hays
Mar 29, 1991·Biochemical and Biophysical Research Communications·S BettuzziC Franceschi
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·T OgiuM Nishimura
Aug 11, 2000·Microscopy Research and Technique·M CaleroJ Ghiso
Jun 15, 1993·Microscopy Research and Technique·A O Welsh

❮ Previous
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