Induction of therapeutic gene silencing in leukocyte-implicated diseases by targeted and stabilized nanoparticles: a mini-review

Journal of Controlled Release : Official Journal of the Controlled Release Society
Dan Peer

Abstract

RNA interference (RNAi) is a highly conserved endogenous mechanism that uses small RNA species to guide the sequence-specific silencing of gene expression. The discovery that RNAi functions in mammalian cells to regulate important cellular processes suggested that harnessing these endogenous gene-silencing pathways can prove to be an effective method for the targeted silencing of gene expression. Yet, the key challenge in translating the discovery of RNAi into a novel therapeutic modality is the lack of effective and safe delivery strategies. Here, we describe the major systemic delivery platforms that have been developed. Focus is given to the development of new strategies to target leukocytes, which are among the most difficult cells to transduce with RNAi. Finally, we discuss our strategies to target subsets of leukocytes using integrin-targeted and stabilized nanoparticles (I-tsNPs).

References

May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Motomu ShimaokaTimothy A Springer
May 20, 2004·Cancer Research·Yoshifumi TakeiTakashi Muramatsu
Sep 3, 2004·Bioorganic & Medicinal Chemistry Letters·Christina LorenzCarlo Unverzagt
Nov 3, 2004·Nucleic Acids Research·Raymond M SchiffelersMartin C Woodle
Dec 28, 2004·Nature Medicine·Vira BitkoSailen Barik
Apr 14, 2005·Blood·Carol A Sledz, Bryan R G Williams
May 24, 2005·Nature Biotechnology·Erwei SongJudy Lieberman
Jul 26, 2005·Nature Biotechnology·David V MorrisseyBarry Polisky
Oct 4, 2005·FEBS Letters·Mohammed AmarzguiouiDongho Kim
Dec 14, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Adam D JudgeIan MacLachlan
Mar 28, 2006·Nature·Tracy S ZimmermannIan MacLachlan
May 17, 2006·The Journal of Infectious Diseases·Thomas W GeisbertIan MacLachlan
Jul 11, 2006·Nature Biotechnology·James O McNamaraPaloma H Giangrande
Jul 13, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hongtao LvJie Yan
Sep 2, 2006·Nucleic Acids Research·Angus T De SouzaRoger G Ulrich
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dan PeerMotomu Shimaoka
Apr 20, 2007·Advanced Drug Delivery Reviews·David L Lewis, Jon A Wolff
Jun 2, 2007·Nature Reviews. Drug Discovery·Antonin de FougerollesJudy Lieberman
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·David B RozemaJon A Wolff
Sep 18, 2007·Nature Biotechnology·Christian WolfrumMarkus Stoffel
Sep 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Derek W BartlettMark E Davis
Oct 10, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shyh-Dar LiLeaf Huang
Nov 9, 2007·Human Gene Therapy·Yoshinari SaitoToshimitsu Uede
Nov 17, 2007·Journal of Assisted Reproduction and Genetics·S M H Andrabi
Jan 31, 2008·Human Gene Therapy·Adam Judge, Ian MacLachlan
Apr 29, 2008·Nature Biotechnology·Akin AkincDaniel G Anderson
Aug 21, 2008·Human Gene Therapy·Marjorie RobbinsIan MacLachlan
Aug 30, 2008·Nature Medicine·Kimi HonmaTakahiro Ochiya
May 28, 2009·Journal of the American Society of Nephrology : JASN·Bruce A MolitorisElena Feinstein
Dec 5, 2009·Nanomedicine·Ranit Kedmi, Dan Peer
Dec 10, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sang-Soo KimPremlata Shankar
Jun 24, 2010·Nature Chemistry·Jeffery T Davis

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Citations

Aug 30, 2011·Accounts of Chemical Research·Xia Guo, Leaf Huang
Aug 24, 2013·International Journal of Nanomedicine·Sidi YangEmmanuel A Ho
Jan 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sidi YangEmmanuel A Ho
Aug 4, 2011·British Journal of Haematology·Sarah ShigdarWei Duan
Apr 5, 2013·Immunological Reviews·Dan Peer
Aug 15, 2013·Cancer Letters·Daniel Rosenblum, Dan Peer
Apr 1, 2016·Journal of Drug Targeting·Srinivas RamishettiDan Peer
Sep 11, 2018·Expert Opinion on Drug Delivery·Ikramy A KhalilHideyoshi Harashima
Apr 19, 2011·Nature Reviews. Genetics·Beverly L Davidson, Paul B McCray
Jan 31, 2020·Advanced Materials·Srinivas RamishettiDan Peer
Jan 1, 2014·Molecular and Cellular Therapies·Dan Peer
Jun 7, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·István TombáczHamideh Parhiz

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