PMID: 3755422Aug 15, 1986Paper

Induction of thymic lymphosarcomas in C57BL/6 mice after inoculation of weakly oncogenic viruses associated with a sub-leukemogenic radiation exposure (1.75 Gy x 2)

International Journal of Cancer. Journal International Du Cancer
M GaliayJ F Duplan

Abstract

B-ecotropic retroviruses arise frequently in old or irradiated C57BL/6 mice as a consequence of a genetic recombination between endogenous eco- and xenotropic retroviruses. They are weakly oncogenic and express a very low tropism for thymic cells. However, their activation by X-rays and the subsequent insertion of new proviral sequences in the cell genome of in vivo- and in vitro-passaged tumors suggest that they might play a role in radioleukemogenesis. To study this possibility, a cloned B-ecotropic virus (1223) was injected into C57BL/6 mice subjected to a subleukemogenenic irradiation which induces only 7% of thymic lymphosarcomas (TL). When it was injected prior to or after irradiation, 1223 induced respectively 31% and 19% of TL. The incidence of TL in the different groups closely correlated with virus expression in hematopoietic tissues during the preleukemic period. Thus, irradiation seems to amplify bone marrow (BM) and thymic cell population(s) which play a decisive role in viral expression. A recombinant provirus (presumably the injected 1223) was detected in the genomic DNA of all tumors tested irrespective of the inductive protocol. BM restoration, which does not inhibit TL produced by highly oncogenic passaged vir...Continue Reading

References

Aug 1, 1979·International Journal of Cancer. Journal International Du Cancer·M LiebermanH S Kaplan
Jan 1, 1979·Advances in Cancer Research·N Haran-Ghera, A Peled
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A DeclèveH S Kaplan
Jan 1, 1970·Advances in Virus Research·G Poste
Jan 1, 1966·International Journal of Cancer. Journal International Du Cancer·N Haran-Ghera
Apr 1, 1981·The Journal of General Virology·H C HolmesR D Barnes
Aug 15, 1982·International Journal of Cancer. Journal International Du Cancer·E LegrandF Laigret
Oct 1, 1953·Journal of the National Cancer Institute·H S KAPLANJ PAULL
Apr 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·L GROSS

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.