PMID: 9180222May 16, 1997Paper

Induction of tolerance and mossy fibre neuropeptide-Y expression in the contralateral hippocampus following a unilateral intrahippocampal kainic acid injection in the rat

Neuroscience Letters
B El BahhA Rougier

Abstract

We have previously reported an ectopic expression of neuropeptide-Y (NPY) immunoreactivity in mossy fibres (MFs) in the contralateral hippocampus following a unilateral intrahippocampal (IH) injection of kainic acid (KA). In the present study we report that, in addition to MF NPY expression, unilateral IH KA injections also induce tolerance towards a subsequent intracerebroventricular (ICV) contralateral KA injection, resulting in a reduction in the number of overt seizures and degree of cell loss.

References

Jan 1, 1991·British Journal of Pharmacology·W F ColmersK A Treherne
Apr 1, 1991·Physiology & Behavior·Z A BortolottoE A Cavalheiro
Jul 15, 1980·The Journal of Comparative Neurology·J V NadlerC W Cotman
Aug 1, 1994·The European Journal of Neuroscience·S D CrollH Nawa
May 2, 1994·Brain Research·W Pohle, C Rauca
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki

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Citations

Apr 20, 2005·Neurobiology of Disease·Venceslas DuveauGildas Le Gal La Salle
Aug 25, 2007·Epilepsy Research·Blair R HespD Steven Kerr
Jan 24, 2007·Neurobiology of Disease·Karin BorgesRaymond Dingledine
Jul 25, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L Covolan, L E Mello

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