PMID: 46255Feb 1, 1975

Induction of tolerance to nucleic acid determinants by administration of a complex of nucleoside D-glutamic acid and D-lysine (D-GL)

The Journal of Immunology : Official Journal of the American Association of Immunologists
Z EshharD H Katz


The administration of nucleosides coupled covalently to the copolymer of D-glutamic acid and D-lysine (D-GL) or to its stereoisomer, L-GL, induces a state of nucleoside (NUC)-specific tolerance in inbred SJL and BALB/c mice, irrespective of their immune status at the time of treatment. Such tolerance is characterized by the inability of treated animals to mount either primary or secondary, intact or adoptive, anti-NUC antibody responses following immunization with a highly immunogenic conjugate of NUC-Keyhole limpet hemocyanin. These observations have potential therapeutic importance in autoimmune processes involving anti-DNA antibody production.

Related Concepts

Mice, Inbred BALB C
Antigenic Specificity
Neonatal Immunity, Maternally-Acquired
Antibody Formation
Fluorescent Antinuclear Antibodies
Normal Serum Globulin Therapy

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