Induction of transferrin secretion in murine Sertoli cells by FSH and IL-1: the possibility of different mechanism(s) of regulation

American Journal of Reproductive Immunology : AJRI
Mahmoud HuleihelM Mazor

Abstract

In the present study we examined the capacity of interleukin-1 (IL-1) alpha, beta, interleukin-1 receptor antagonist (IL-1ra) and follicle stimulating hormone (FSH) to induce transferrin secretion by Sertoli cells under in vitro conditions. Primary Sertoli cell (SC) cultures from immature mice secreted constitutively transferrin. Stimulation of these cultures with IL-1alpha, IL-1beta significantly increas\d their capacity to secrete transferrin. Addition of IL-1ra to unstimulated SC cultures did not affect their capacity to secrete transferrin. Stimulation of SC cultures with a combination of both IL-1alpha and FSH or IL-1beta and FSH showed additive effect between IL-1 and FSH in their capacity to induce transferrin secretion by these cells. However, stimulation of Sertoli cells with a combination of both IL-1ra and FSH did not affect their capacity to secrete transferrin compared with FSH-stimulated cultures. Our results may suggest the involvement of testicular paracrine/autocrine factors (IL-1) and endocrine (FSH) factors in the regulation of transferrin secretion by SC. This capacity seems to be differently regulated by these factors. Thus, IL-1alpha and beta may directly affect physiological functions of the testis; which...Continue Reading

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Mar 29, 2001·American Journal of Reproductive Immunology : AJRI·M HuleihelM Mazor

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Citations

May 4, 2002·Molecular and Cellular Endocrinology·Mahmoud Huleihel, Eitan Lunenfeld
Jan 18, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mahmoud Abu ElheijaMahmoud Huleihel
Jan 26, 2006·American Journal of Reproductive Immunology : AJRI·Mahmoud Abu ElhijaMahmoud Huleihel
Aug 13, 2003·Cell Transplantation·Dwaine F EmerichCraig R Halberstadt
Mar 27, 2019·Cell Proliferation·Sara ChiappalupiGuglielmo Sorci
Dec 7, 2018·Leukemia & Lymphoma·Yulia MichailovMahmoud Huleihel
Dec 2, 2020·International Journal of Molecular Sciences·Gianna RossiMauro Maccarrone

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