PMID: 9182817Jun 1, 1997Paper

Induction of tumor necrosis factor-alpha in vivo by a skin irritant, tributyltin, through activation of transcription factors: its pharmacological modulation by anti-inflammatory drugs

The Journal of Investigative Dermatology
E CorsiniC L Galli

Abstract

Skin irritant reactions are under the control of a network of cytokines and lipid mediators. This study characterized the production of tumor necrosis factor-alpha (TNF) induced by a skin irritant treatment, tributyltin (TBT), in mice through transcription factor activation and its pharmacologic modulation by anti-inflammatory agents. The ears of BALB/c mice were painted with different amounts of TBT (67-536 nmol in acetone) or with acetone alone. At different times thereafter, TNF production was analyzed both at the mRNA and protein level, by semiquantitative RT-PCR and L929 cytotoxicity assay, respectively. TBT induced rapid (1 h) TNF gene expression and protein synthesis. Maximal TNF production was observed 2 h after treatment. The production of TNF was paralleled by accumulation of skin water; this was partially prevented by intraperitoneal injection of antibody against murine TNF. These data indicate that skin irritation induced by TBT is attributable, in addition to the actions of other inflammatory mediators, to the action of keratinocyte-derived TNF. TNF production was preceded by a rapid (5 min) activation of nuclear factor-kappaB (NF-kappaB), which was also maximal 30 min after treatment. TBT-induced accumulation of s...Continue Reading

References

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Nov 1, 1996·The Journal of Investigative Dermatology·E CorsiniC L Galli

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Citations

Nov 18, 2000·Annals of the New York Academy of Sciences·M I LusterJ M Matheson
Sep 2, 2000·Journal of Biochemical and Molecular Toxicology·D G AllenN A Monteiro-Riviere
Mar 13, 2010·Aging Cell·Haruyoshi YamazaIsao Shimokawa
Feb 22, 2011·Journal of Medicinal Food·Jehun ChoiHae Young Chung
Jun 20, 2003·Journal of Biochemical and Molecular Toxicology·James V RogersJames N McDougal
Nov 7, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·James N McDougalSteven J Berberich
Mar 11, 2011·Journal of Toxicology and Environmental Health. Part a·Nela Pavlikova, Augustine Arukwe
Dec 29, 2013·Mediators of Inflammation·Haur Yueh LeeMasato Kakeda
Nov 1, 2004·Environmental Health and Preventive Medicine·Ken NakanoNobuhiro Konno
Apr 27, 2001·Toxicology Letters·M I LusterB Yucesoy
Jul 17, 2007·Journal of Agricultural and Food Chemistry·Jae Heun ChungHae Young Chung
Jul 26, 2003·The Journal of Investigative Dermatology·Emmanuela CorsiniMarina Marinovich

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