PMID: 7543022Jun 1, 1995Paper

Induction of tumor-specific T lymphocyte responses in vivo by prothymosin alpha

Cancer Immunology, Immunotherapy : CII
C N BaxevanisM Papamichail

Abstract

We have recently reported that administration of ProT alpha to DBA/2 mice before the inoculation of syngeneic L1210 leukemic cells prolonged the survival of these animals by (a) inducing tumoricidal peritoneal macrophages, (b) enhancing natural killer (NK) and inducing lymphokine-activated killer (LAK) activities in splenocytes and (c) inducing the production of interleukin-2 and tumor necrosis factor alpha [Papanastasiou et al. (1992) Cancer Immunol Immunother 35:145; Baxevanis et al. (1994) Cancer Immunol Immunothera 38:281]. In this report we demonstrated that ProT alpha, when administered simultaneously with L1210 tumor cells, is capable of generating in DBA/2 animals tumor-specific CD8+ cytotoxic T lymphocytes (CTL). The ProT alpha-induced CD8+ CTL lysed their syngeneic L1210 targets in a major histocompatibility complex (MHC)-restricted fashion since monoclonal antibodies (mAb) against the H-2Kd allelic product could inhibit the cytotoxic response. Mice receiving only ProT alpha developed non-MHC-restricted cytotoxic activity (NK, and LAK activities) whereas those receiving ProT alpha and L1210 tumor cells developed both MHC-restricted (CTL) and non-MHC-restricted cytotoxic activities and survived longer. The ProT alpha-i...Continue Reading

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Citations

Mar 1, 2012·Cancer Immunology, Immunotherapy : CII·Kyriaki IoannouOurania E Tsitsilonis
Jan 1, 1997·Immunology Today·O J CorderoM Nogueira
Apr 16, 2014·Virchows Archiv : an International Journal of Pathology·Yuh-Shyan TsaiTzong-Shin Tzai
Jan 2, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ioannis F VoutsasAristotelis Bamias
May 3, 2007·Proteomics·Margarita SkopelitiOurania E Tsitsilonis
Jan 18, 2015·Developmental and Comparative Immunology·Zhangang XiaoQionglin Guo
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ai-Li ShiauChao-Liang Wu
Dec 1, 2001·Biological Chemistry·A PiñeiroM Nogueira
Dec 13, 2005·Clinical and Diagnostic Laboratory Immunology·Yanwen JinQingjun Ma
Feb 12, 2005·World Journal of Surgery·Changyi ChenQizhi Yao
Aug 13, 2005·Molecular Membrane Biology·Francisco J SalgadoMontserrat Nogueira

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