Type I diabetes mellitus is an autoimmune disease resulting from the interaction of genetic and environmental factors. A virus that was identified serologically as Kilham's rat virus (KRV) was isolated from a spontaneously diabetic rat and reproducibly induced diabetes in naive diabetes-resistant (DR) BB/Wor rats. Viral antigen was not identified in pancreatic islet cells, and beta cell cytolysis was not observed until after the appearance of lymphocytic insulitis. KRV did not induce diabetes in major histocompatibility complex-concordant and discordant non-BB rats and did not accelerate diabetes in diabetes-prone BB/Wor rats unless the rats had been reconstituted with DR spleen cells. This model of diabetes may provide insight regarding the interaction of viruses and autoimmune disease [corrected]
Role of apoptosis in the regulation of virus-induced T cell responses, immune suppression, and memory
Preservation of GLUT 2 expression in islet beta cells of Kilham rat virus (KRV)-infected diabetes-resistant BB/Wor rats
Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes
Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness
Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells)
Bovine serum albumin and insulin-dependent diabetes mellitus; is cow's milk still a possible toxicological causative agent of diabetes?
High frequency of cross-reactive cytotoxic T lymphocytes elicited during the virus-induced polyclonal cytotoxic T lymphocyte response
Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice
Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes
Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere
Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice
Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone (DP) BB rats
DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes
Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms
Kilham Rat Virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis
Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research
Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes
Alteration of aortic function from streptozotocin-diabetic rats with Kilham's virus is associated with inducible nitric oxide synthase
Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.
Autoimmune Diabetes & Tolerance
Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.