PMID: 43646Jan 1, 1979

Induction of tyrosine aminotransferase in galactosamine hepatitis

Acta gastroenterologica Latinoamericana
H R PuggeR J Pellanda

Abstract

We have induced acute hepatitis in rats with the amino sugar Galactosamine by i.p. injection. The development of the disease was controlled by measurements of several metabolites and enzymes in serum, and light and electronic microscopy. Tyrosine transaminase was induced by i.p. injection of Cortisol, that increases ten times enzyme activity in liver parenchyma of normal rats. This inductive phenomenon cannot be observed in animals with galactosamine hepatitis. We discuss the probable mechanism and their relationship with some forms of viral hepatitis in human beings.

Related Concepts

Amino Sugars
Enzymes, antithrombotic
Tyrosine Aminotransferase
Drug-Induced Acute Liver Injury
Enzyme Activity
Mucopolysaccharidosis IV
Enzymes for Treatment of Wounds and Ulcers
Liver Parenchyma
Microscopy
Blood Enzyme Activity (Lab Test)

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