Induction of uterine hemangioendothelioma and lymphoma in (C57BL/6N x C3H/2N)F1 mice by oral administration of azathioprine

Japanese Journal of Cancer Research : Gann
A ItoM Naito

Abstract

The tumorigenicity of 6-(1-methyl-4-nitro-5-imidazolyl)mercaptopurine (azathioprine), an immunosuppressant, was examined in (C57BL/6N X C3H/2N)F1 mice. Animals were divided into 6 groups with 50 mice in each group, and they were given powdered diet mixed with 0, 5 or 20 ppm azathioprine starting at 6 weeks and ending at 100 weeks of age. Female mice, given 20 ppm azathioprine, developed lymphomas and uterine hemangioendotheliomas at incidences of 12.5 and 14.6%, respectively, which were significantly higher than the incidences in control mice (P less than 0.05). Lymphoma and uterine hemangioendothelioma developed independently in different mice. On the other hand, the male mice given 20 ppm azathioprine had a significantly (P less than 0.05) lower incidence of hepatic tumor (0.5%) compared to the control mice (16%).

References

Feb 1, 1979·International Journal of Cancer. Journal International Du Cancer·J J HarveyF E Katz
Sep 1, 1979·Journal of the National Cancer Institute·J M WardM S Linhart
Jan 1, 1987·Transplantation·I Penn
Mar 1, 1986·Transplantation·H ShinozukaM I Perera
Apr 1, 1983·The Australian Journal of Experimental Biology and Medical Science·A W Thomson

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Citations

Apr 16, 2014·Mutation Research. Reviews in Mutation Research·David A EastmondBabasaheb Sonawane
Oct 11, 2008·Mutation Research·Giovanni Brambilla, Antonietta Martelli
Apr 25, 2007·Scandinavian Journal of Urology and Nephrology·Balagopal NairThomas Appu
Dec 1, 1992·Risk Analysis : an Official Publication of the Society for Risk Analysis·L S GoldB N Ames
Dec 5, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiJan M Zielinski

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