Induction of vascular leak syndrome by tumor necrosis factor-alpha alone

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Kyung-Yeon ParkTae-Hwe Heo

Abstract

Although TNF-α possesses promising anticancer activity, clinical application is limited partly due to cardiovascular toxicities. TNF-α effects on vessels are likely related to vascular toxicity, but much remains poorly understood. Similarly, IL-2 is an attractive treatment option for cancers but its clinical use is limited by the side effect of vascular leak syndrome (VLS). We report here that TNF-α alone can trigger VLS. Administration of recombinant TNF-α induced VLS in normal mice and TNF-α transgenic mice exhibited VLS. Perivascular infiltrates in the lungs and specific cytokines in serum were observed in VLS-induced mice. This study shed a new light on the critical role of the TNF-α in IL-2-induced or non IL-2-induced VLS and provides important points to TNF-α therapy.

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Citations

Feb 19, 2016·Parasites & Vectors·R Alan WilsonWilliam Castro-Borges
Sep 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kyung-Yeon ParkTae-Hwe Heo
May 10, 2017·DNA and Cell Biology·Berlin Londono-RenteriaTonya M Colpitts
Feb 5, 2019·Immunopharmacology and Immunotoxicology·Hae-Ri LeeTae-Hwe Heo
Nov 13, 2019·Clinical and Experimental Pharmacology & Physiology·Hae-Ri LeeTae-Hwe Heo
Nov 19, 2020·Open Forum Infectious Diseases·Hélène MascittiIsabelle Bourgault-Villada
Nov 12, 2017·Biochemical and Biophysical Research Communications·Jin-Gyo OhTae-Hwe Heo

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