Induction of WNT inhibitory factor 1 expression by Müllerian inhibiting substance/antiMullerian hormone in the Müllerian duct mesenchyme is linked to Müllerian duct regression

Developmental Biology
Joo Hyun ParkJ Teixeira

Abstract

A key event during mammalian sexual development is regression of the Müllerian ducts (MDs) in the bipotential urogenital ridges (UGRs) of fetal males, which is caused by the expression of Müllerian inhibiting substance (MIS) in the Sertoli cells of the differentiating testes. The paracrine signaling mechanisms involved in MD regression are not completely understood, particularly since the receptor for MIS, MISR2, is expressed in the mesenchyme surrounding the MD, but regression occurs in both the epithelium and mesenchyme. Microarray analysis comparing MIS signaling competent and Misr2 knockout embryonic UGRs was performed to identify secreted factors that might be important for MIS-mediated regression of the MD. A seven-fold increase in the expression of Wif1, an inhibitor of WNT/β-catenin signaling, was observed in the Misr2-expressing UGRs. Whole mount in situ hybridization of Wif1 revealed a spatial and temporal pattern of expression consistent with Misr2 during the window of MD regression in the mesenchyme surrounding the MD epithelium that was absent in both female UGRs and UGRs knocked out for Misr2. Knockdown of Wif1 expression in male UGRs by Wif1-specific siRNAs beginning on embryonic day 13.5 resulted in MD retention...Continue Reading

References

Feb 20, 2003·Trends in Endocrinology and Metabolism : TEM·Nathalie Josso, Nathalie di Clemente
May 31, 2003·Journal of Cell Science·Yoshiaki Kawano, Robert Kypta
Nov 25, 2003·Nature Reviews. Genetics·Akio Kobayashi, Richard R Behringer
Apr 10, 2004·Development·Mathias MericskayDavid Sassoon
May 10, 2005·Human Reproduction Update·Nathalie JossoJean-Yves Picard
May 12, 2006·American Journal of Medical Genetics. Part a·Petra Kraus, Thomas Lufkin
Oct 31, 2006·Developmental Biology·Silvana GuioliRobin Lovell-Badge
Dec 5, 2006·Oncogene·A J Mikels, R Nusse
Feb 29, 2008·Development·Maria LoscertalesDrucilla J Roberts
Sep 4, 2008·Science Signaling·Renée van AmerongenRoel Nusse
Apr 15, 2011·Development·Akio KobayashiRichard R Behringer
Jul 10, 2012·Developmental Biology·Renée van AmerongenRoel Nusse

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Citations

Apr 30, 2015·Gene·Wei-Lai DongWan-Xi Yang
May 29, 2015·Arab Journal of Urology·Mahmoud M ShalabyMohamed F Abdelhafez
Oct 4, 2019·Environmental Epigenetics·Malcolm M Moses, Richard R Behringer
Aug 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Rachel D MullenRichard R Behringer
Aug 15, 2020·Frontiers in Endocrinology·Vimal SelvarajDouglas M Stocco

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