Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies

Environmental Research
Sasha BernatskyMarvin J Fritzler

Abstract

To determine the association of anti-citrullinated antibodies (ACPA) with the ambient air pollutants fine particulate matter (PM2.5) and sulfur dioxide (SO2). The CARTaGENE first-wave cohort includes 20,000 general population subjects from Quebec (Canada). On a sample of unselected 1586 subjects, we determined serum, ACPA and performed multivariable logistic regression, for the outcome of positive ACPA, assessing for independent effects of our air pollution variables, adjusting for age, sex, smoking, and French Canadian origin. Two models assessed distance to main industrial emitters of PM2.5, and of SO2, and two models assessed tons of SO2 and of PM2.5 annual emissions. We also assessed associations with PM2.5 regional ambient concentrations estimated with satellite imagery. Adjusted analyses suggested a positive association between annual industrial PM2.5 and SO2 emissions and the presence of ACPA antibodies (OR: 1.02, 95%CI 1.00-1.04 per 10t of PM2.5 and 100t of SO2). The data were also consistent with a negative association between the presence of ACPA, and distance to a major industrial emitter of both PM2.5 and SO2. We found no association with PM2.5 estimates of ambient levels. These analyses suggest that exposure to ind...Continue Reading

Citations

Dec 24, 2017·Respiratory Research·Jill A PooleGeoffrey M Thiele
Sep 20, 2018·Journal of Toxicology and Environmental Health. Part a·Jean C PfauMarvin J Fritzler
Jul 31, 2020·Environmental Health : a Global Access Science Source·Naizhuo ZhaoSasha Bernatsky
Dec 19, 2018·International Journal of Environmental Research and Public Health·Shih-Yi LinChia-Hung Kao
Mar 7, 2020·Current Opinion in Rheumatology·Lauren C PriscoJeffrey A Sparks
Mar 11, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Johanna SigauxMarie-Christophe Boissier
Aug 28, 2021·International Journal of Environmental Research and Public Health·Francesca IngegnoliRoberto Caporali
Apr 13, 2020·Revue des maladies respiratoires·L SeséH Nunes

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