Industrial hygiene and toxicity studies in unorganized bone-based industrial units.

Environmental Monitoring and Assessment
Huma SiddiquiIqbal Ahmad

Abstract

A large variety of ornamental and decorative items are manufactured from bone waste by various unorganized sectors in India. An initial survey indicated that workers were exposed at various phases of final product. The subjects (12 industrial units) were tested for total suspended particulate matter (TSPM), particulate matter <10 microm (PM(10)), and particulate matter <2.5 microm (PM(2.5)). Prevalent levels of TSPM ranged between 2.90 and 5.89 mg m(-3). Respirable fractions of occupational dust as PM(10) and PM(2.5) were found in the range of 0.30-2.08 and 0.26-0.50 mg m(-3), respectively. Cytotoxicity study was conducted using hemolysis as a sensitive marker. In an in vitro study, rat RBCs were exposed to the concentration of 25-1,000 microg/ml for 15-120 min. A considerable variation was observed in the hemolytic activity of samples collected from different areas. At 500 microg/ml concentration, the hemolytic activity (12 h) was found to be in the range of 18-25%. Due to limitation in sample mass of respirable fractions, only one concentration (100 microg/ml/2 h) was used for comparative study on hemolysis of RBCs caused by PM(10) and PM(2.5). Interestingly, the hemolytic activity was more at PM(2.5) than PM(10) and TSPM. Th...Continue Reading

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Citations

Sep 29, 2011·Environmental Monitoring and Assessment·Muhammad Wajid TahirMuddsar Iqbal

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