Industrial use of immobilized enzymes

Chemical Society Reviews
Robert DiCosimoGregory Bohlmann

Abstract

Although many methods for enzyme immobilization have been described in patents and publications, relatively few processes employing immobilized enzymes have been successfully commercialized. The cost of most industrial enzymes is often only a minor component in overall process economics, and in these instances, the additional costs associated with enzyme immobilization are often not justified. More commonly the benefit realized from enzyme immobilization relates to the process advantages that an immobilized catalyst offers, for example, enabling continuous production, improved stability and the absence of the biocatalyst in the product stream. The development and attributes of several established and emerging industrial applications for immobilized enzymes, including high-fructose corn syrup production, pectin hydrolysis, debittering of fruit juices, interesterification of food fats and oils, biodiesel production, and carbon dioxide capture are reviewed herein, highlighting factors that define the advantages of enzyme immobilization.

References

Sep 1, 1975·Journal of Agricultural and Food Chemistry·R A Messing, A M Filbert
Mar 1, 1990·Applied Microbiology and Biotechnology·K NakanishiR Matsuno
Jul 1, 1990·Enzyme and Microbial Technology·P LozanoF Romojaro
Mar 1, 1990·Applied Biochemistry and Biotechnology·Y B Tewari
Jan 1, 1990·Annals of the New York Academy of Sciences·K Nakanishi, R Matsuno
Feb 1, 1990·The Biochemical Journal·W VangrysperreH Kersters-Hilderson
Apr 1, 1985·The American Journal of Clinical Nutrition·D A FinleyL E Grivetti
Oct 1, 1973·FEBS Letters·S GiovencoP Pansolli
May 1, 1972·Biotechnology and Bioengineering·G W Strandberg, K L Smiley
Feb 11, 1984·British Medical Journal·L S Taitz, B L Armitage
May 14, 1980·Biochemical and Biophysical Research Communications·P Y WangH Schneider
Aug 1, 1983·The American Journal of Clinical Nutrition·J BitmanN R Mehta
Jan 1, 1993·Journal of Chemical Technology and Biotechnology·A Wiseman
Jan 1, 1997·Pharmacology & Therapeutics·S Lindskog
Sep 23, 1998·Trends in Biotechnology·K E Jaeger, M T Reetz
Jun 29, 1999·Current Opinion in Microbiology·W D Crabb, Jay K Shetty
Dec 1, 1999·Bioorganic & Medicinal Chemistry·J D Rozzell
Jan 11, 2001·Biochimica Et Biophysica Acta·B S HartleyM Rangarajan
Mar 15, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·H YamadaM Kobayashi
Oct 10, 2002·Current Protein & Peptide Science·B Asbóth, G Náray-Szabó
Jan 4, 2003·Journal of Medicinal Food·Gilbert V Levin
Jun 5, 2003·Annals of the New York Academy of Sciences·R M CowanM C Trachtenberg
Aug 29, 2003·Current Opinion in Biotechnology·Linqiu CaoRoger A Sheldon
Apr 5, 1957·Science·R O MARSHALL, E R KOOI
Oct 11, 2003·Biotechnology Advances·Munish Puri, U C Banerjee
Jan 1, 1987·Biotechnology Advances·H N Chang
Jan 30, 2004·Acta Crystallographica. Section D, Biological Crystallography·B Leif HansonGerard J Bunick
Mar 31, 2004·The American Journal of Clinical Nutrition·George A BrayBarry M Popkin
Jul 16, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·Y W Wang, P J H Jones
Nov 4, 2004·Progress in Lipid Research·Klaus W J WahleDino Rotondo
Jun 4, 2005·Biotechnology Progress·Phillip R GibbsAndreas S Bommarius
Jul 7, 2005·Journal of Agricultural and Food Chemistry·Torben H RønneXuebing Xu
Aug 17, 2005·Bioresource Technology·M D BustoM Perez-Mateos
Apr 25, 2006·Bioresource Technology·D RoyonS Locatelli
May 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Amy K KatzGerard J Bunick
Mar 8, 2007·Nano Letters·Chenghong LeiEric J Ackerman
May 26, 2007·Biotechnology Advances·Byron C H Chu, Hung Lee
Jun 2, 2007·Biotechnology Letters·Tuoping LiCheyun Zhang
Oct 2, 2007·Journal of Agricultural and Food Chemistry·Casimir C AkohJei-Fu Shaw
Nov 23, 2007·Biochemical Society Transactions·Roger A Sheldon
Jan 22, 2008·Journal of Industrial Microbiology & Biotechnology·Palligarnai T Vasudevan, Michael Briggs
Apr 19, 2008·Applied Biochemistry and Biotechnology·Kripa RaoSasidhar Varanasi
May 15, 2008·Applied Biochemistry and Biotechnology·Leng Hong Lim, Bradley A Saville
Mar 1, 1982·Biotechnology and Bioengineering·F H Verhoff, W E Goldstein
May 20, 1988·Biotechnology and Bioengineering·A L CrumblissR W Henkens
Apr 5, 1989·Biotechnology and Bioengineering·D B Volkin, A M Klibanov
Feb 20, 1993·Biotechnology and Bioengineering·J Y HoungC Tiu
Sep 23, 2008·Regulatory Toxicology and Pharmacology : RTP·Bruce G HammondTammye Fleeman
Nov 6, 2008·ChemSusChem·Kai Man Kerry YuShik Chi Edman Tsang
Dec 4, 2008·Critical Reviews in Biotechnology·Kenthorai Raman JegannathanPogaku Ravindra
Dec 10, 2008·The American Journal of Clinical Nutrition·John S White
Jan 27, 2009·Chemical Society Reviews·Ulf HanefeldEdmond Magner
Mar 10, 2009·Biotechnology Advances·A Robles-MedinaE Molina-Grima
May 5, 2009·Critical Reviews in Biotechnology·Wilson Parawira
Jul 18, 2009·Journal of Agricultural and Food Chemistry·Jean-Michel GietGeorges Lognay
Aug 20, 2009·Applied Biochemistry and Biotechnology·Mário A P NunesMaria H Ribeiro
Oct 22, 2009·Journal of Oleo Science·Siew Wai Lin, Saw Mei Huey
Nov 28, 2009·Applied Microbiology and Biotechnology·Ah-Reum Park, Deok-Kun Oh
Feb 4, 2010·Chemical Communications : Chem Comm·Renliang HuangZhimin He
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Manuel MolinerMark E Davis
Apr 1, 2010·Journal of the Science of Food and Agriculture·Prakash AdhikariKi-Teak Lee
Jun 29, 2010·Biotechnology Advances·Tianwei TanFang Wang
Aug 11, 2010·Applied Microbiology and Biotechnology·Laura AzócarRodrigo Navia
Sep 4, 2010·Environmental Science & Technology·Jeroen B GuinéeTomas Rydberg
Nov 23, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Célia MartinsAntónio S Rodrigues
May 6, 2011·Applied Microbiology and Biotechnology·Maria H Ribeiro
May 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shilpa N Bhupathiraju, Katherine L Tucker
Jun 1, 2011·Biotechnology Advances·Philippe DemarcheSpiros N Agathos
Jun 18, 2011·Gene·Carlos J Alméciga-DíazOscar F Sánchez
Nov 28, 2006·Nanotechnology·Chenghong LeiEric J Ackerman
Jul 9, 2011·Current Opinion in Biotechnology·Christopher K Savile, James J Lalonde
Jul 23, 2011·Applied Microbiology and Biotechnology·Fernando SoriaLuiz Bezerra Carvalho
Aug 13, 2011·Journal of Agricultural and Food Chemistry·Sarah A Teichert, Casimir C Akoh
Sep 6, 2011·Journal of Bioscience and Bioengineering·Laura AzócarRodrigo Navia
Nov 15, 2011·Applied Microbiology and Biotechnology·Munish Puri
Nov 16, 2011·Applied Microbiology and Biotechnology·Baohua ZhangZhiping Mao
Dec 3, 2011·Enzyme and Microbial Technology·C R SilvaR L C Giordano
Dec 6, 2011·Journal of Industrial Microbiology & Biotechnology·Hajer Ben HlimaSamir Bejar
Jan 25, 2012·Colloids and Surfaces. B, Biointerfaces·Joey N Talbert, Julie M Goddard
Jan 31, 2012·Microporous and Mesoporous Materials : the Official Journal of the International Zeolite Association·Yuehua YuJun Liu
Apr 25, 2012·Applied Biochemistry and Biotechnology·Felipe GuioOscar F Sánchez
May 25, 2012·ChemSusChem·Philipp M GrandePablo Domínguez de María
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ricardo Bermejo-DevalMark E Davis
Aug 18, 2012·Biotechnology Research International·Sheetal Bhasin, H A Modi
Jul 1, 2010·Anesthesia, Essays and Researches·Yasser Mohamed AmrAbd-Almohsen M Hammad
Dec 1, 1987·Biotechnology Letters·P LozanoJ L Iborra

Citations

Apr 12, 2014·Chemical Communications : Chem Comm·Yanjun JiangJing Gao
Jun 7, 2014·Applied Microbiology and Biotechnology·Inge J MintenMarco A van den Berg
Aug 15, 2014·Journal of Industrial Microbiology & Biotechnology·Rúbia Carvalho Gomes CorrêaRosane Marina Peralta
Nov 14, 2014·Journal of the Royal Society, Interface·Mailin MissonBo Jin
Jul 28, 2015·Sensors·Soo ChungSeong In Cho
Jul 10, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min WangQuanshun Li
Jun 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rubens A SilvaDenise F S Petri
Aug 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martina C C PintoJosé Carlos Pinto
Jun 4, 2015·Critical Reviews in Biotechnology·Sung In Lim, Inchan Kwon
Nov 7, 2014·Critical Reviews in Biotechnology·Sonia JemliSamir Bejar
Feb 2, 2016·Enzyme and Microbial Technology·Ashwini C MathpatiBhalchandra M Bhanage
Sep 16, 2015·Biotechnology and Bioengineering·Michele ZanoniEoin Casey
Jan 7, 2016·Frontiers in Plant Science·Claudia KochChristina Wege
Mar 5, 2016·Chemical Reviews·Farid KhelifaPhilippe Dubois
Mar 12, 2016·International Journal of Biological Macromolecules·Dilek AlagözDeniz Yildirim
Mar 24, 2016·The Journal of Physical Chemistry. B·Megumi KayanumaYasuteru Shigeta
Jun 4, 2015·International Journal of Biological Macromolecules·Bihong LvGuohua Jing
Jan 7, 2015·Biotechnology Advances·Jose M Palomo, Marco Filice
Apr 19, 2015·Microbial Cell Factories·Maik BartschRobert Kourist
Apr 24, 2016·Applied Microbiology and Biotechnology·Christoph A GasserPhilippe F-X Corvini
Jan 8, 2015·Applied Biochemistry and Biotechnology·Ashani SamaratungaScott W Pryor
May 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nazzoly RuedaRoberto Fernandez-Lafuente
Jun 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara PeirceRoberto Fernandez-Lafuente
Jun 15, 2016·Scientific Reports·Jiandong CuiShiru Jia
Jun 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui RenQuanshun Li
Aug 31, 2016·Biomacromolecules·Iris Beatriz Vega ErramuspePedro Fardim
Sep 23, 2016·International Journal of Molecular Sciences·Jakub ZdartaTeofil Jesionowski
Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ummirul Mukminin KaharKian Mau Goh
Oct 9, 2016·Biotechnology Progress·Sercan KaravJuliana M L N de Moura Bell
Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paolo ZuccaEnrico Sanjust
Sep 27, 2016·Scientific Reports·Xiao-Fei ZhangYan Feng
Mar 30, 2017·Applied Biochemistry and Biotechnology·Xiaomei WanYi Hu
Apr 5, 2017·ACS Applied Materials & Interfaces·Huan WangYuanjin Zhao
Apr 22, 2017·Chemical Communications : Chem Comm·Xiaoling WuHui Wu
May 4, 2017·Chemical Communications : Chem Comm·Christine Guérard-HélaineThierry Gefflaut
Mar 14, 2017·Chemical Society Reviews·Roger A Sheldon, Pedro C Pereira
Apr 5, 2017·Organic & Biomolecular Chemistry·M B QuinClaudia Schmidt-Dannert
May 27, 2017·Chemical Communications : Chem Comm·Jia Jia DongFrank Hollmann
Dec 14, 2016·ChemistryOpen·Hans-Christian RothSonja Berensmeier
Jun 19, 2017·Environmental Science and Pollution Research International·Dhanya VishnuHubert Cabana
Feb 22, 2017·International Journal of Biological Macromolecules·Jiandong CuiShiru Jia
Jan 31, 2017·Colloids and Surfaces. B, Biointerfaces·Ibrahim Nasser AhmedWei-Bor Tsai
Feb 12, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Nasibeh HaghighiAbdollah Salimi
Apr 27, 2017·Biotechnology and Applied Biochemistry·Edgar Edurman García-SilveraMaría R Trejo-Hernández
Mar 12, 2015·Nanoscale·Soňa HermanováZdeněk Sofer
Nov 11, 2017·Biotechnology Journal·Horst LechnerWolfgang Kroutil
Feb 28, 2018·Biotechnology Journal·Jaehyun Cha, Inchan Kwon
Dec 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana D Q MeloFrancisco A Dias Filho
Nov 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shang-Ming HuangChwen-Jen Shieh
Jan 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min YangZhimeng Wu
Oct 12, 2016·Chemical Communications : Chem Comm·Shunmugavel SaravanamuruganSebastian Meier
Aug 6, 2016·Angewandte Chemie·Joshua BrittonGregory A Weiss
Jan 9, 2018·Biochemistry Insights·Keith J Stine
Sep 28, 2017·Chemistry : a European Journal·Fernando López-GallegoLorena Betancor
Aug 22, 2014·Nature Chemistry·Martin FischlechnerFlorian Hollfelder
May 18, 2018·Chemical Communications : Chem Comm·Roger A Sheldon, Dean Brady
Jun 30, 2019·Biotechnology Progress·Lucas Dal MagroRoberto Fernandez-Lafuente
Oct 15, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jinseok Heo
Aug 22, 2019·Electrophoresis·Flora W Y Chiu, Stavros Stavrakis
Nov 12, 2019·Physical Chemistry Chemical Physics : PCCP·Zhongwang FuZheng Liu
Oct 28, 2019·International Journal of Molecular Sciences·Luuk MestromPeter-Leon Hagedoorn
Jun 24, 2016·Beilstein Journal of Nanotechnology·Claudia KochChristina Wege
Jan 15, 2020·Bioprocess and Biosystems Engineering·Maria de Fátima Matos de FreitasLuciana Rocha Barros Gonçalves
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aleksandra LeśniarekWitold Gładkowski
Jul 1, 2017·Green Chemistry : an International Journal and Green Chemistry Resource : GC·Tanja KnausFrancesco G Mutti
Jun 26, 2020·Natural Product Reports·Silja Mordhorst, Jennifer N Andexer
Jun 27, 2020·Biotechnology and Applied Biochemistry·Emily H Edwards, Kara L Bren
Jun 20, 2020·Angewandte Chemie·Shuke WuUwe T Bornscheuer
Nov 12, 2015·Frontiers in Bioengineering and Biotechnology·Marlene PröschelUwe Sonnewald
Feb 27, 2017·Applied Biochemistry and Biotechnology·Jéssica Bravin Carmello Dos SantosPaulo Waldir Tardioli
Mar 13, 2017·Applied Biochemistry and Biotechnology·Li-Qun JinYu-Guo Zheng
Dec 3, 2016·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Asaf IlovitshOrit Shefi
Jan 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jose J Virgen-OrtízRoberto Fernandez-Lafuente
Oct 8, 2017·Bioprocess and Biosystems Engineering·Tássia Silva TavaresTeodorico C Ramalho
May 26, 2018·Chemical Society Reviews·Louis LancasterIan Wheeldon
Nov 7, 2018·Acta Crystallographica. Section C, Structural Chemistry·Xiao-Jing SangZai Ming Zhu
Sep 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan M Bolivar, Bernd Nidetzky
Feb 15, 2017·Applied Biochemistry and Biotechnology·Armin SadighiMehdi Khoobi
Sep 30, 2017·Biotechnology Journal·Lili JiaNoriho Kamiya
Sep 3, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Geng Dong, Ulf Ryde
Nov 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José Renato GuimarãesPaulo Waldir Tardioli
Aug 17, 2019·The Journal of Biological Chemistry·Benjamin SchmuckMats Sandgren
Sep 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiayi SongYi Yang
May 16, 2020·Frontiers in Chemistry·Natalia Mariano CabralJean Marcel R Gallo
Aug 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hanna GustafssonPeter Walde
Jun 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sindy EscobarFernando López-Gallego
Feb 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongli MaoYoshihiro Ito
Jun 28, 2020·Critical Reviews in Food Science and Nutrition·Maria Micaela UretaAndrea Gomez-Zavaglia
Sep 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jose J Virgen-OrtízRoberto Fernandez-Lafuente
Aug 28, 2020·Microbial Cell Factories·Prem ChandraPankaj Kumar Arora
May 12, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Nazzoly RuedaRoberto Fernandez-Lafuente
Oct 27, 2016·Physical Chemistry Chemical Physics : PCCP·Daohui Zhao, Jian Zhou
Jan 27, 2015·Chembiochem : a European Journal of Chemical Biology·Jennifer N Andexer, Michael Richter
Sep 15, 2016·Environmental Science and Pollution Research International·Paola CalzaEnzo Laurenti
Sep 24, 2017·Chemistry : a European Journal·Ana I Benítez-MateosFernando López-Gallego
Jan 30, 2019·Frontiers in Bioengineering and Biotechnology·Barbara SchmiegMatthias Franzreb
Sep 27, 2018·Current Protein & Peptide Science·Jean-Étienne R L Morlighem, Gandhi Radis-Baptista
Nov 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinpeng WangZhengyu Jin
Apr 3, 2019·ChemSusChem·Roger A Sheldon, Dean Brady
Nov 3, 2018·International Journal of Molecular Sciences·Jully L FragaPriscilla F F Amaral
Nov 4, 2019·Nature Communications·Tz-Han WeiFa-Kuen Shieh
Sep 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pingping HanHong Wu
Aug 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Julie Credou, Thomas Berthelot
Mar 21, 2020·Frontiers in Bioengineering and Biotechnology·Jin Xiang WongBernd H A Rehm
Nov 19, 2015·Microbial Cell Factories·Ilka SührerKathrin Castiglione
Aug 2, 2018·Applied Microbiology and Biotechnology·Sarah Schmidt-DannertClaudia Schmidt-Dannert
Jun 28, 2019·Advanced Synthesis & Catalysis·Christiane ClaaßenDörte Rother
Mar 19, 2019·Catalysts·Joshua L CohenJuliana M L N de Moura Bell
May 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wesley BöhmerFrancesco G Mutti
Oct 1, 2015·Angewandte Chemie·Kyriaki ManoliLuisa Torsi
May 6, 2019·Chemistry : a European Journal·Karl P J GustafsonJan-E Bäckvall
Jul 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tatyana G TerentyevaKatsuhiko Ariga
Aug 26, 2018·Scientific Reports·Bradley S HeaterMichael K Chan
Nov 5, 2020·Bioprocess and Biosystems Engineering·Bin YuanAiling Liu
Nov 13, 2020·Biotechnology and Applied Biochemistry·Chinmayi BhattJohn M Woodley
Dec 4, 2020·Macromolecular Rapid Communications·Huan WangHanying Zhao
Jul 16, 2020·Biotechnology Advances·Sara Arana-PeñaRoberto Fernandez-Lafuente
Oct 30, 2020·International Journal of Biological Macromolecules·Chika Jude Ugwuodo, Tochukwu N Nwagu
Nov 5, 2019·Trends in Biotechnology·Michael V ArbigeGopal K Chotani
Jan 12, 2021·Biomacromolecules·Sandro Martins de OliveiraJose Manuel Guisán
Dec 11, 2019·ACS Applied Materials & Interfaces·Natasha Lynn SmithSanford A Asher
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Yalong GuoQiang Wang
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Carminna OttoneLorena Wilson
Feb 9, 2021·International Journal of Biological Macromolecules·Chan Hee LeeEe Taek Hwang
Feb 10, 2021·Journal of Colloid and Interface Science·Yuxiao FengJiandong Cui
Mar 27, 2020·ChemSusChem·Sudripet SharmaSachin Handa
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Olga Luisa TavanoRoberto Fernandez-Lafuente
Feb 17, 2021·International Journal of Biological Macromolecules·Carlos Alberto Chaves Girão NetoMaria Valderez Ponte Rocha

Related Concepts

Chemical Industry
Biocatalysis
Carbon Dioxide
Immobilization
Oils
Pectin
Anabolism
Fruit Juices
Low Fat Food
Corn Syrup

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