Industry-funded versus non-profit-funded critical care research: a meta-epidemiological overview

Intensive Care Medicine
Perrine JaniaudJohn P A Ioannidis

Abstract

To study the landscape of funding in intensive care research and assess whether the reported outcomes of industry-funded randomized controlled trials (RCTs) are more favorable. We systematically assembled meta-analyses evaluating any type of intervention in the critical care setting and reporting the source of funding for each included RCT. Furthermore, when the intervention was a drug or biologic, we searched also the original RCT articles, when their funding information was unavailable in the meta-analysis. We then qualitatively summarized the sources of funding. For binary outcomes, separate summary odds ratios were calculated for trials with and without industry funding. We then calculated the ratio of odds ratios (RORs) and the summary ROR (sROR) across topics. ROR < 1 implies that the experimental intervention is relatively more favorable in trials with industry funding compared with trials without industry funding. For RCTs included in the ROR analysis, we also examined the conclusions of their abstract. Across 67 topics with 568 RCTs, 88 were funded by industry and another 73 had both industry and non-profit funding. Across 33 topics with binary outcomes, the sROR was 1.10 [95% CI (0.96-1.26), I2 = 1%]. Conclusions were...Continue Reading

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Jul 12, 2019·Frontiers in Neurology·Mirja KrauseRebecca Lim
Oct 25, 2020·European Heart Journal. Quality of Care & Clinical Outcomes·Chris J KapeliosElias Mossialos

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