Indwelling pleural catheter versus talc pleurodesis for malignant pleural effusion: a meta-analysis.

Clinical & Experimental Metastasis
Maggie YeungKa-Wai Tam

Abstract

Malignant pleural effusion (MPE) results from primary mesothelioma or the spreading of metastatic cancer. Both talc pleurodesis (TP) and indwelling pleural catheter (IPC) improve MPE symptoms. We performed a meta-analysis of randomized controlled trials to compare the efficacy of TP with that of IPC in patients with MPE. PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov databases were searched for studies published before February 2020. Individual effect sizes were standardized, and a meta-analysis was conducted to calculate a pooled effect size by using random effects models. In total, 4 trials with 500 patients were reviewed. Difference in pleurodesis success rate and change in dyspnea scores at 4 and 6 weeks between MPE patients treated with IPC and those treated with TP for pleurodesis were nonsignificant. The number of hospital inpatient days was significantly lower among patients who were treated with IPC (weight mean difference: 2.19; 95% confidence interval 0.70-3.67) than among those who were treated with TP. No significant difference was shown in adverse event profile between patients treated with IPC and those treated with TP for pleurodesis. In conclusion, both TP and IPC are equally effective in treating pat...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 28, 2010·Thorax·Mark E RobertsUNKNOWN BTS Pleural Disease Guideline Group
Aug 11, 2010·Journal of General Internal Medicine·Margaret E M Van MeterR Jeffrey Kohlwes
Apr 12, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M HerdmanX Badia
Apr 20, 2012·The Annals of Thoracic Surgery·Ben M HuntJed A Gorden
Apr 26, 2013·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Nadim SrourShawn Aaron
May 9, 2016·The Cochrane Database of Systematic Reviews·Amelia O CliveNick Maskell
Mar 9, 2017·Expert Review of Respiratory Medicine·José M PorcelY C Gary Lee
Jun 20, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·R C BoshuizenM M van den Heuvel
Apr 5, 2018·The New England Journal of Medicine·Rahul BhatnagarNick A Maskell
Sep 19, 2018·Respiration; International Review of Thoracic Diseases·Rachelle AsciakNajib Mahboob Rahman

❮ Previous
Next ❯

Citations

Nov 23, 2020·General Thoracic and Cardiovascular Surgery·Eleftherios T BeltsiosNikolaos Panagiotopoulos

❮ Previous
Next ❯

Software Mentioned

Review Manager
PROSPERO

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Rogier C BoshuizenMichel M van den Heuvel
Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Nadim SrourShawn Aaron
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
L BertolacciniAlberto Terzi
© 2022 Meta ULC. All rights reserved