Ineffective perfusion-contraction matching in conscious, chronically instrumented pigs with an extended period of coronary stenosis

Circulation Research
Raymond K KudejS F Vatner

Abstract

Several models purported to represent hibernating myocardium involve a coronary stenosis (CS) to reduce blood flow (BF) and function without eliciting necrosis in anesthetized pigs. The goal of the present study was to determine whether sustained moderate reduction in coronary BF in conscious pigs induced hibernating myocardium, ie, perfusion-contraction matching with no necrosis. These experiments were conducted in conscious pigs chronically instrumented with a coronary artery BF probe and hydraulic occluder, left ventricular (LV) pressure gauge, and wall thickening (WT) crystals in the potentially ischemic and nonischemic zones. The hydraulic occluder was inflated to induce a stable 41+/-4% reduction in BF for 24 hours. Ischemic zone systolic WT fell initially with CS and then continued to decline during the period of CS even though blood flow did not change further, suggesting the induction of myocardial stunning. At 2 days after release of CS, WT was still depressed by 48+/-15%. Assessment of necrosis by histology or triphenyltetrazolium chloride showed 40+/-5% multifocal patchy necrosis interspersed with normal tissue involving the inner one third to one half of the ventricular wall. Regional myocardial BF (radioactive mic...Continue Reading

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Citations

Jun 2, 2007·Heart Failure Reviews·Christophe Depre, Stephen F Vatner
Feb 1, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·John M Canty, James A Fallavollita
Jul 25, 2003·Journal of Molecular and Cellular Cardiology·Raymond K Kudej, Stephen F Vatner
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Jul 17, 1998·The New England Journal of Medicine·W WijnsP G Camici
Nov 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Sunil BaldwaJames A Fallavollita
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·C DepreS F Vatner
Aug 9, 2001·Coronary Artery Disease·J M Canty, J A Fallavollita
Jan 11, 2012·The International Journal of Cardiovascular Imaging·Kiyotake IshikawaRoger J Hajjar
Sep 6, 2011·Journal of Molecular and Cellular Cardiology·John M Canty, Gen Suzuki
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Yoriyasu SuzukiFumiaki Ikeno
Jul 26, 2005·Trends in Cardiovascular Medicine·Christophe Depre, Stephen F Vatner
Jan 24, 2015·Basic Research in Cardiology·Lin YanStephen F Vatner
Mar 9, 2011·Journal of Molecular and Cellular Cardiology·Gerd HeuschRainer Schulz
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyGerd Heusch
Jan 31, 2004·American Journal of Physiology. Heart and Circulatory Physiology·J Michael O'DonnellE Douglas Lewandowski
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Feb 4, 2021·Nature Reviews. Cardiology·Gerd Heusch

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