PMID: 11313118Apr 21, 2001Paper

Ineffectiveness of activated carbon in reducing the alteration of sphingolipid metabolism in rats exposed to fumonisin-contaminated diets

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M SolfrizzoA Visconti

Abstract

Sphinganine/sphingosine (SA/SO) ratio, a biomarker of fumonisin exposure, has been measured in urine, kidney and liver of male Wistar rats exposed to fumonisin-contaminated diet with and without the addition of activated carbon (AC). The latter was previously shown to adsorb fumonisin B(1) in vitro. Rats were fed either control diet or fumonisin-contaminated diet (4 microg FB(1+)FB(2)/g) or fumonisin-contaminated diet mixed with 20 mg AC/g diet for 1 week. In rats fed fumonisin-contaminated diet, the SA concentration and SA/SO ratio increased significantly and reversibly in kidney, while urine and liver did not show a significant increase of SA/SO ratio. The addition of AC to the fumonisin-contaminated diet did not alter the change of SA/SO biomarker for fumonisin exposure. This provides indications that the use of AC to reduce the toxicity of fumonisins is unlikely to be effective in vivo.

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Citations

Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giuseppina AvantaggiatoAngelo Visconti
Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giuseppina AvantaggiatoAngelo Visconti
Apr 5, 2003·Toxicology Letters·M R CarratùV Cuomo
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·K Jen, E J Squires
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·K Jen, E J Squires
Jun 10, 2011·Journal of Agricultural and Food Chemistry·Zhiyi QiangSuzanne Hendrich
Jul 16, 2005·Food Additives and Contaminants·G AvantaggiatoA Visconti
Feb 18, 2010·Acta Veterinaria Hungarica·Miklós MézesKatalin Tóth
Feb 11, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Muzaffer DenliJose F Pérez
Nov 20, 2009·Journal of Biotechnology·Stefan HeinlReingard Grabherr
Dec 24, 2003·Public Health Nutrition·Sharon Kirkpatrick, Valerie Tarasuk
May 22, 2013·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Andrea BaglieriMichèle Nègre

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