Ineffectiveness of methylprednisolone in the treatment of pulmonary dysfunction after cardiopulmonary bypass

American Journal of Surgery
L H CoffinJ G Morgan

Abstract

Fifty consecutive adults undergoing elective cardiac surgery with cardiopulmonary bypass received a single dose of methylprednisolone (30 mg/kg) at the time of anesthesia. The results were compared with those in the immediately preceding fifty adult patients who underwent elective cardiac surgery and who did not receive corticosteroids. The age, sex, and weight of the patient, mortality, nature of the lesions treated surgically, bypass time, smoking history, physiologic evidence of preexisting lung disease, preoperative New York Heart Association class, preoperative left ventricular end diastolic pressure, incidence and duration of the postoperative low cardiac output syndrome, postoperative arrhythmias, operative and postoperative blood loss and postoperative hours of respiratory support, dynamic lung-thorax compliance, alveolar arterial oxygen gradient, fraction of wasted ventilation, and incidence of tracheostomy were tabulated and statistically contrasted. The two groups were comparable relative to all preoperative factors, except for a slightly higher end diastolic pressure in the patients who received steroids. Methylprednisolone given at the time of anesthesia was associated with a higher intraoperative blood loss, a hig...Continue Reading

References

Sep 3, 1973·JAMA : the Journal of the American Medical Association·R Llamas, H J Forthman
Mar 1, 1974·Canadian Anaesthetists' Society Journal·K W TurnbullA N Gerein
Apr 1, 1964·The Journal of Clinical Investigation·G M GREEN, E H KASS

❮ Previous
Next ❯

Citations

Dec 10, 1989·Transfusion Science·W van OeverenM D Kazatchkine
Mar 29, 2006·The Journal of Surgical Research·R P WhitlockK H Teoh
Apr 29, 2014·American Heart Journal·Richard WhitlockSalim Yusuf
Mar 10, 2001·The Journal of Thoracic and Cardiovascular Surgery·M A ChaneyM Bakhos
May 13, 2011·The Cochrane Database of Systematic Reviews·Jan M DielemanOlaf M Dekkers
Dec 17, 1987·The New England Journal of Medicine·G R BernardC A Metz
May 4, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Richard P WhitlockKevin H Teoh
Jun 12, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Giangiuseppe CappabiancaDomenico Paparella

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.