Inefficient N2-Like Neutrophils Are Promoted by Androgens During Infection

Frontiers in Immunology
María V ScalerandiAmado A Quintar

Abstract

Neutrophils are major effectors of acute inflammation against infection and tissue damage, with ability to adapt their phenotype according to the microenvironment. Although sex hormones regulate adaptive immune cells, which explains sex differences in immunity and infection, little information is available about the effects of androgens on neutrophils. We therefore aimed to examine neutrophil recruitment and plasticity in androgen-dependent and -independent sites under androgen manipulation. By using a bacterial model of prostate inflammation, we showed that neutrophil recruitment was higher in testosterone-treated rats, with neutrophil accumulation being positively correlated to serum levels of testosterone and associated to stronger inflammatory signs and tissue damage. Testosterone also promoted LPS-induced neutrophil recruitment to the prostate, peritoneum, and liver sinusoids, as revealed by histopathology, flow cytometry, and intravital microscopy. Strikingly, neutrophils in presence of testosterone exhibited an impaired bactericidal ability and a reduced myeloperoxidase activity. This inefficient cellular profile was accompanied by high expression of the anti-inflammatory cytokines IL10 and TGFβ1, which is compatible wit...Continue Reading

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Citations

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Methods Mentioned

BETA
lavage
flow cytometry
electron microscopy
Protein Assay
electrophoresis
dot blot
dot blots
ELISA
confocal microscopy

Software Mentioned

Fiji
FlowJo X
Volocity
GraphPad Prism
SPSS

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