Inefficient termination of antigen responses in NF-ATp-deficient mice

Immunobiology
J HeyerE Serfling

Abstract

In order to elucidate the role of NF-ATp, one of the most prominent members of family of NF-AT transcription factors in peripheral T lymphocytes, in T cell activation and differentiation we created NF-ATp-deficient mice by gene targeting. Such NF-ATp-/- mice are born and appear to develop a normal immune system. Apart from clear-cut defects in the synthesis of mRNAs for Th2-type lymphokines, such as IL-4, IL-5, IL-10 and IL-13, in primary and secondary stimulations of spleen cells in vitro, of a distinct impaired deletion of V beta 11+/CD4+ T lymphocytes from these mice was detected after superantigen injection. Moreover, NF-ATp-/- mice older than 6 weeks show an 2-5 fold increase in number of lymphocytes. This is correlated with an increased expression of activation markers CD44 and CD69 and decreased expression of CD62.

Citations

Jun 3, 2000·Annual Review of Immunology·K M MurphyT L Murphy
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·J HeyerR Kucherlapati
Mar 28, 2007·Seminars in Immunology·Sanmay BandyopadhyayFernando Macián
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrej KhandogaFritz Krombach
May 6, 2015·The Journal of Clinical Investigation·Ludovic DesvignesStefan Feske
Jan 12, 2002·The Journal of Biological Chemistry·Bin ZhouH Scott Baldwin
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J TramaS N Ho

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