Abstract
If acute leukemia is the most frequent cancer in childhood (33%), it remains a very rare diagnosis in infants less than one year old, e.g. less than 5% of cases. At this age, the frequency of acute lymphoblastic leukemia (ALL) (almost all of B-lineage) is quite similar to the one of myeloblastic forms (AML). Infant leukemia frequently presents with high hyperleucocytosis, major tumoral burden and numerous extra-hematological features, especially in central nervous system and skin. Whatever the lineage, the leukemic cell is often very immature cytologically and immunologically. Rearrangements of the Mixed Lineage Leukemia (MLL) gene, located on band 11q23, are the hallmark of these immature leukemias and confer a particular resistance to conventional approaches, corticosteroids and chemotherapy. The immaturity of infants less than 1-year-old is associated to a decrease of the tolerable dose-intensity of some drugs (anthracyclines, alkylating agents) or asks questions about some procedures like radiotherapy or high dose conditioning regimen, responsible of inacceptable acute and late toxicities. The high level of severe infectious diseases and other high-grade side effects limits also the capacity to cure these infants. The survi...Continue Reading
References
Jul 15, 1991·Cancer Genetics and Cytogenetics·A BaruchelR Berger
Feb 1, 1994·British Journal of Haematology·A FersterG Souillet
Jan 1, 1994·The Journal of Clinical Investigation·P H SorensenJ H Kersey
May 27, 1993·Nature·A M FordM Greaves
Jan 1, 1997·Journal of Pediatric Hematology/oncology·L S FrankelD J Pullen
Dec 24, 1997·Cancer·L B SilvermanS E Sallan
Nov 7, 1999·Lancet·J L WiemelsM F Greaves
Jan 19, 2000·Leukemia·J BernsteinF Viguie
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T MercherO A Bernard
Dec 12, 2001·Blood·H KawasakiE Ishii
Jun 12, 2002·Lancet·Ching-Hon PuiBruce Camitta
Aug 30, 2002·British Journal of Haematology·Keiichi IsoyamaEiichi Ishii
Feb 15, 2003·Blood·Johann K HitzlerAlvin Zipursky
May 22, 2003·Journal of Pediatric Hematology/oncology·Hart Isaacs
Jun 14, 2003·Leukemia & Lymphoma·Eiichi IshiiMariko Eguchi
Feb 16, 2006·Blood·Jun NagayamaUNKNOWN Japan Infant Leukemia Study Group
Mar 25, 2006·Blood·Joanne M HildenUNKNOWN Children's Oncology Group
Apr 28, 2007·Science·Frédéric BarabéJohn E Dick
Jul 31, 2007·Lancet·Rob PietersMaria Grazia Valsecchi
Feb 13, 2009·Leukemia·V H J Van der VeldenUNKNOWN Interfant-99 Study Group
Aug 7, 2009·Blood·Marieke H van der LindenRob Pieters
Jul 2, 2010·Blood·Georg MannUNKNOWN Interfant-99 Study Group
Oct 22, 2011·Leukemia·D J P M StumpelR W Stam
May 1, 2013·Leukemia·C MeyerR Marschalek
Jun 27, 2013·Blood·Scott R DaigleRoy M Pollock
Apr 2, 2015·Therapeutic Advances in Hematology·Colleen E Annesley, Patrick Brown
Apr 18, 2015·Molecular Immunology·Gerhard ZugmaierMarion Subklewe