Infant acute leukemia

Bulletin du cancer
Benoît BrethonA Baruchel

Abstract

If acute leukemia is the most frequent cancer in childhood (33%), it remains a very rare diagnosis in infants less than one year old, e.g. less than 5% of cases. At this age, the frequency of acute lymphoblastic leukemia (ALL) (almost all of B-lineage) is quite similar to the one of myeloblastic forms (AML). Infant leukemia frequently presents with high hyperleucocytosis, major tumoral burden and numerous extra-hematological features, especially in central nervous system and skin. Whatever the lineage, the leukemic cell is often very immature cytologically and immunologically. Rearrangements of the Mixed Lineage Leukemia (MLL) gene, located on band 11q23, are the hallmark of these immature leukemias and confer a particular resistance to conventional approaches, corticosteroids and chemotherapy. The immaturity of infants less than 1-year-old is associated to a decrease of the tolerable dose-intensity of some drugs (anthracyclines, alkylating agents) or asks questions about some procedures like radiotherapy or high dose conditioning regimen, responsible of inacceptable acute and late toxicities. The high level of severe infectious diseases and other high-grade side effects limits also the capacity to cure these infants. The survi...Continue Reading

References

Jul 15, 1991·Cancer Genetics and Cytogenetics·A BaruchelR Berger
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Nov 7, 1999·Lancet·J L WiemelsM F Greaves
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Apr 28, 2007·Science·Frédéric BarabéJohn E Dick
May 1, 2013·Leukemia·C MeyerR Marschalek
Jun 27, 2013·Blood·Scott R DaigleRoy M Pollock
Apr 2, 2015·Therapeutic Advances in Hematology·Colleen E Annesley, Patrick Brown

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Citations

Mar 7, 2021·Cancers·Charlotte CalvoFrançoise Méchinaud

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