Abstract
On average 185 children are diagnosed each year in France with a cancer in their first year of life, representing 11 % of cancers diagnosed in children less than 15 years. A retrospective population-based observational study was conducted between 2000 and 2014 of all infants with a diagnosis of cancer using the National Registry of Childhood Cancers Database. Out of 2760 cases of primary cancers in infancy, there were mainly neuroblastomas 30.1 %), central nervous system (CNS) tumors (16.1 %), leukemias (15.3 %), retinoblastomas (11.6 %), and Wilms tumors (6.9 %). Embryonal malignancies accounted for 55.2 % of cases. Most diagnoses showed a male excess, particularly for malignant gonadal germ-cell tumors (GCT) with a 17.5 sex-ratio. The annual incidence rate, 242.9 per million infants overall, was stable over the study period for all types of cancer. Most deaths occurred within the first month of life (70.8 % of deaths). The 5-year overall survival (5-y OS) was 81.0 % (95 %CI, 79.4-82.4) with large contrasts between diagnoses. The best 5-y OS (>85 %) were observed for retinoblastomas, carcinomas, nephroblastomas, GCT, neuroblastomas, and hepatoblastomas. Conversely, the lowest 5-y OS (<65 %) were observed for acute myeloid leuk...Continue Reading
References
Jan 1, 1977·British Journal of Cancer·R PetoP G Smith
Jan 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J Shuster
Feb 16, 2005·Cancer·Eva Steliarova-FoucherPeter Kaatsch
Mar 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara HeroFrank Berthold
Apr 28, 2009·American Journal of Perinatology·Hart Isaacs
Apr 3, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Brigitte LacourJacqueline Clavel
Jul 30, 2011·Pediatric Blood & Cancer·Thien N SamJulie A Ross
Aug 4, 2011·Archives of Pathology & Laboratory Medicine·Roger E McLendonSusan M Blaney
Oct 3, 2013·Cold Spring Harbor Perspectives in Medicine·Miller Huang, William A Weiss
Nov 28, 2013·The Lancet Oncology·Daniel OrbachFrançois Doz
Jan 29, 2014·Neuro-oncology·Emmanuel DesandesBrigitte Lacour
May 23, 2014·Neuro-oncology·Quinn T OstromJill S Barnholtz-Sloan
Jul 11, 2014·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Brigitte LacourJacqueline Clavel
Oct 1, 2014·Archives of Pathology & Laboratory Medicine·Melissa Bombery, Jo-Anne Vergilio
Mar 18, 2015·Nature Reviews. Clinical Oncology·Kathryn G Roberts, Charles G Mullighan
Jun 26, 2015·PloS One·Giun-Yi HungChih-Ying Lee
Jul 29, 2015·Blood·Hiroto InabaSusana C Raimondi
Oct 16, 2015·Blood·Alejandra Sanjuan-PlaPablo Menéndez
Dec 29, 2015·Cancer·Daria ThompsonSteven G DuBois
Apr 5, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Di CataldoA Cañete
Apr 20, 2016·Pediatric Blood & Cancer·Emmanuel DesandesBrigitte Lacour
Oct 26, 2016·International Journal of Cancer. Journal International Du Cancer·Jessica L Barrington-TrimisRoberta McKean-Cowdin
Jan 20, 2017·Oncology Letters·Yi ZhangTian Zhi
Jun 18, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anita VillaniChristian P Kratz
Jun 24, 2017·Cancer Medicine·Ahmad S AlfaarIbrahim Qaddoumi
Jan 6, 2018·Pediatric Hematology and Oncology·Anne-Charlotte TeyssierGuy Leverger
Mar 8, 2019·Nature Reviews. Endocrinology·Frédéric BrioudeIrene Netchine