Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition.

Clinical and Experimental Immunology
R Y ChoiKeith R Fowke

Abstract

The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio (HR) = 1.92, 95% confidence interval (CI) 1.05, 3.50, P = 0.03; adjusted HR = 2.03, 95% CI 1.03, 3.98, P = 0.04], after adjusting for maternal viral load. This SNP (an allele frequency of approximately 15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers.

References

Jan 16, 1999·Journal of Clinical Microbiology·D D PanteleeffJ Overbaugh

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Citations

Sep 10, 2011·AIDS Research and Human Retroviruses·Robert Y ChoiCarey Farquhar
Feb 10, 2011·Journal of Translational Medicine·Mariangela Cavarelli, Gabriella Scarlatti
Jan 23, 2015·AIDS Research and Human Retroviruses·Yu LuShan Li
Mar 23, 2017·Frontiers in Public Health·Hafiza Fizzah ZulfiqarTayyab Husnain
Oct 21, 2017·Immunogenetics·Fany BlancEmmanuelle Bourneuf
Oct 7, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Branwen J HennigGiorgio Sirugo
Nov 11, 2019·Veterinary Immunology and Immunopathology·Francesco GrandoniGiovanna De Matteis

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