Infant Exposure to Methylphenidate and Duloxetine During Lactation

Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine
Laurence Collin-LévesqueEma Ferreira

Abstract

Duloxetine and methylphenidate are commonly prescribed for the management of depression and attention-deficit/hyperactivity disorder (ADHD), respectively. However, little information is available concerning their safety during lactation. The purpose of this case series was to provide additional information to the medical literature concerning infant exposure to methylphenidate and duloxetine through breast milk. Bioanalytical method (liquid chromatography coupled to mass spectrometry) was developed and validated before its use to determine the concentrations of both medications in breast milk samples. Case 1: A 30-year-old woman with depression and ADHD took duloxetine 90 mg daily and methylphenidate 36 mg daily during pregnancy and breastfeeding. The newborn was found to have a congenital pulmonary airway malformation. The breastfeeding status was nonexclusive. At week 4 postpartum, the concentration found in the milk was 32.8 ng/mL of duloxetine and 7.9 ng/mL of methylphenidate (estimated relative infant dose [RID] of 0.3% and 0.2%, respectively). Case 2: A 41-year-old women with depression took duloxetine 60 mg daily during pregnancy and lactation. She gave birth to a healthy child. The breastfeeding status was nonexclusive....Continue Reading

References

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Citations

Dec 29, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Georgios SchoretsanitisOlav Spigset
Feb 1, 2021·Neuroscience and Biobehavioral Reviews·Sarah Kittel-SchneiderAndreas Reif

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