Infant feeding practice and later obesity risk. Indications for early metabolic programming

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Berthold KoletzkoVeit Grote

Abstract

Metabolic factors acting during limited and sensitive time periods of pre- and postnatal development can induce lasting effects on health and disease risk in later life up to old age, including later obesity risk, which is referred to as early metabolic programming of long-term health. Three meta-analyses of observational studies found that obesity risk at school age was reduced with early breastfeeding compared to formula feeding. We assumed that breastfeeding protects against later obesity by reducing the occurrence of high weight gain in infancy and that one causative factor is the lower protein content of human milk compared to usual infant formulas (the "early protein hypothesis"). We are testing this hypothesis in the European Childhood Obesity Project, a double-blind, randomized clinical trial enrolling 1,678 infants in five countries (Belgium, Germany, Italy, Poland, Spain). We have randomized healthy infants born at term to receive for the first year infant formula and follow-on formula with higher or lower protein contents, respectively. The follow-up data obtained at age 2 years indicates that feeding formula with reduced protein content normalizes early growth relative to a breastfed reference group and the current ...Continue Reading

References

Nov 17, 1990·BMJ : British Medical Journal·D J Barker
Jan 22, 1974·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R A McCance, E M Widdowson
Oct 1, 1994·Archives of Disease in Childhood·A Lucas
Dec 31, 1997·BMJ : British Medical Journal·H T SørensenT I Sørensen
Aug 6, 1998·Biology of the Neonate·K G Dewey
Feb 16, 1999·The American Journal of Clinical Nutrition·R A Waterland, C Garza
Jul 16, 1999·BMJ : British Medical Journal·R von KriesH von Voss
Aug 8, 2002·Pediatrics·Michael S KramerUNKNOWN PROBIT Study Group
Sep 27, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P O A MonteiroL M A Monteiro
May 5, 2004·Archives of Pediatrics & Adolescent Medicine·Andre Michael ToschkeRüdiger von Kries
Aug 18, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S ArenzR von Kries
Nov 3, 2004·The Journal of Pediatrics·Michael S KramerUNKNOWN Promotion of Breastfeeding Intervention Trials Study Group
Apr 20, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·P O A Monteiro, C G Victora
Aug 4, 2005·American Journal of Epidemiology·Thomas HarderAndreas Plagemann
Sep 3, 2005·Advances in Experimental Medicine and Biology·Berthold Koletzko
Sep 3, 2005·Advances in Experimental Medicine and Biology·Berthold KoletzkoUNKNOWN EU Childhood Obesity Project
Oct 18, 2005·BMJ : British Medical Journal·Janis BairdCatherine Law
Nov 9, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M JeffreysG Davey Smith
Jun 20, 2006·Physiology & Behavior·D S Fernandez-Twinn, S E Ozanne
Apr 21, 2007·Journal of Internal Medicine·D J P Barker
Dec 25, 2008·The Journal of Nutrition·Michael S KramerStanley Shapiro
Jan 1, 2009·The American Journal of Clinical Nutrition·Simon Rückinger, Rüdiger von Kries
Feb 21, 2009·Advances in Experimental Medicine and Biology·K G Dewey
Mar 5, 2009·European Journal of Medical Research·P KalkB Hocher
Mar 27, 2009·The American Journal of Clinical Nutrition·Berthold KoletzkoVeit Grote
Apr 24, 2009·The American Journal of Clinical Nutrition·Berthold KoletzkoUNKNOWN European Childhood Obesity Trial Study Group
Jun 19, 2009·Advances in Experimental Medicine and Biology·Berthold KoletzkoUNKNOWN European Childhood Obesity Trial Study Group
Oct 16, 2009·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Laurie A Nommsen-Rivers, Kathryn G Dewey

❮ Previous
Next ❯

Citations

Jul 16, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·A LanferW Ahrens
Feb 25, 2011·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·A Reeske, J Spallek
Nov 5, 2013·The Journal of Pediatrics·Karen BonuckChristel Hyden
Mar 26, 2015·PloS One·Kittipan RerkasemApiwat Mutirangura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Clinical Nutrition
Berthold KoletzkoVeit Grote
Advances in Experimental Medicine and Biology
Berthold KoletzkoEuropean Childhood Obesity Trial Study Group
Nestlé Nutrition Institute Workshop Series
Berthold KoletzkoEuropean Childhood Obesity Trial Study Group
© 2021 Meta ULC. All rights reserved