Infant Hospitalizations and Mortality After Maternal Vaccination

Pediatrics
Lakshmi SukumaranEric S Weintraub

Abstract

The Advisory Committee on Immunization Practices currently recommends pregnant women receive influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines. There are limited studies of the long-term safety in infants for vaccines administered during pregnancy. We evaluate whether maternal receipt of influenza and Tdap vaccines increases the risk of infant hospitalization or death in the first 6 months of life. We included singleton, live birth pregnancies in the Vaccine Safety Datalink between 2004 and 2014. Outcomes were infant hospitalizations and mortality in the first 6 months of life. We performed a case-control study matching case patients and controls 1:1 and used conditional logistic regression to estimate odds ratios for maternal exposure to influenza and/or Tdap vaccines in pregnancy. There were 413 034 live births in our population. Of these, 25 222 infants had hospitalizations and 157 infants died in the first 6 months of life. We found no association between infant hospitalization and maternal influenza (adjusted odds ratio: 1.00; 95% confidence interval [CI]: 0.96-1.04) or Tdap (adjusted odds ratio: 0.94; 95% CI: 0.88-1.01) vaccinations. We found no association between infant mor...Continue Reading

Citations

May 8, 2020·The Pediatric Infectious Disease Journal·Dayna R ClarkUNKNOWN for BMGF Supported Maternal Influenza Immunization Trials Investigators Group
Oct 28, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eleonora BrilloErsilia Buonomo
Sep 19, 2019·Infectious Diseases and Therapy·Caroline D'HeillyDenis Macina
Sep 3, 2020·Human Vaccines & Immunotherapeutics·Helen SkirrowBeate Kampmann
May 28, 2021·The Pediatric Infectious Disease Journal·Petra Zimmermann, Christine E Jones
Jun 5, 2021·Human Vaccines & Immunotherapeutics·Md Jahangir AlamShaikh Meshbahuddin Ahmad
Oct 13, 2021·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Taylor L FussRebecca B Perkins

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