Infant nasal nitric oxide over time: natural evolution and impact of respiratory tract infection

The European Respiratory Journal
June K MarthinKim G Nielsen

Abstract

Nasal nitric oxide (NO) discriminates between patients with primary ciliary dyskinesia (PCD) and healthy individuals. We report feasibility of measurement and natural evolution of nasal NO and upon the impact of respiratory tract infection (RTI) on nasal NO in healthy infants (HI), followed from birth until age 2 years, with comparison to nasal NO in infant PCD.Tidal-breathing nasal NO measurements were performed at scheduled visits at 2 weeks old and at 4, 8, 12, 18 and 24 months old, with extra visits during RTIs. Historical nasal NO measurements for infant PCD were included for comparison.Altogether, 224 nasal NO measurements were performed in 44 enrolled infants. Median newborn nasal NO was 46 ppb (interquartile range (IQR) 29-69 ppb), increasing at a rate of 5.4% per month up to 283 ppb (IQR 203-389 ppb) at the age of 2 years. RTIs in 27 out of 44 infants temporarily suppressed nasal NO by 79%. Values for nasal NO in seven infants with PCD ranged from 6-80 ppb. The success rate to accept nasal NO sampling was 223 out of 224 measurements (99.6%).Tidal-breathing nasal NO measurement was indeed feasible in infancy and nasal NO in HI increased significantly up to 2 years of age, in opposition to nasal NO in PCD cases, which st...Continue Reading

References

Apr 1, 1995·Nature Medicine·J O LundbergK Alving
Aug 1, 1994·The European Respiratory Journal·J O LundbergK Alving
Jul 1, 1996·Pediatric Research·U SchedinC Frostell
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·H NakanoJ Iwamoto
May 8, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D ColantonioG K Scadding
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Apr 3, 2008·Pediatric Pulmonology·David E BrownStephanie D Davis
Oct 3, 2009·The European Respiratory Journal·M PifferiA L Boner
Nov 26, 2009·Biometrical Journal. Biometrische Zeitschrift·An CreemersMichael G Kenward
Feb 20, 2010·American Journal of Respiratory and Critical Care Medicine·June K MarthinKim G Nielsen
Jun 8, 2010·The European Respiratory Journal·J K Marthin, K G Nielsen
Jun 10, 2010·The European Respiratory Journal·C E KuehniUNKNOWN ERS Task Force on Primary Ciliary Dyskinesia in Children
Nov 16, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·G L PiacentiniA L Boner
Sep 29, 2011·Thorax·Kent GreenKim Gjerum Nielsen
Mar 13, 2012·The European Respiratory Journal·Woolf T WalkerJane S Lucas
Sep 13, 2013·Annals of the American Thoracic Society·Margaret W LeighMichael R Knowles
Oct 18, 2014·The European Respiratory Journal·Samuel A CollinsJane S A Lucas
Nov 26, 2014·Pediatrics·Tara MullowneySharon Dell
Mar 4, 2015·Pediatric Pulmonology·Nicole BeydonMuriel Le Bourgeois
Aug 4, 2015·Respiratory Medicine·Phillip S AdamsCecilia W Lo
Sep 30, 2015·Pediatric Pulmonology·Adam J ShapiroUNKNOWN Genetic Disorders of Mucociliary Clearance Consortium
Aug 6, 2016·The European Respiratory Journal·Myrofora GoutakiClaudia E Kuehni
Nov 12, 2016·The European Respiratory Journal·Jane S LucasClaudia E Kuehni
Jul 27, 2017·Expert Review of Respiratory Medicine·Jane S LucasWoolf T Walker

❮ Previous
Next ❯

Citations

Jun 23, 2018·The European Respiratory Journal·Jane S Lucas, Woolf T Walker
Nov 27, 2019·Annals of the American Thoracic Society·Adam J ShapiroMargaret W Leigh
Jun 25, 2020·BMC Proceedings·Laura E GardnerClaire Hogg
Sep 19, 2020·Nature Reviews. Disease Primers·Julia WallmeierHeymut Omran
May 3, 2019·ERJ Open Research·Raffaella NennaJonathan Grigg
May 19, 2020·Paediatric Respiratory Reviews·Lucy Morgan
Apr 17, 2021·Pediatric Pulmonology·Nicole BeydonGuillaume Thouvenin
Sep 28, 2021·Pediatric Pulmonology·Flurina BuechelAndreas Jung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

L'Infirmière du Québec : revue officielle de l'Ordre des infirmières et infirmiers du Québec
M Lachapelle, F Lacroix St-Laurent
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
L BahbahL Ouzidane
Annals of Dermatology
Talita Ribeiro Tenório de FrançaDanyel Elias da Cruz Perez
Pediatric Radiology
Mauro OddonePaolo Toma
Otolaryngologia polska. The Polish otolaryngology
A Skuratowicz, A Soboczyński
© 2022 Meta ULC. All rights reserved