Infant Nutritional Status and Markers of Environmental Enteric Dysfunction are Associated with Midchildhood Anthropometry and Blood Pressure in Tanzania

The Journal of Pediatrics
Lindsey M LocksChristopher P Duggan

Abstract

To assess whether growth and biomarkers of environmental enteric dysfunction in infancy are related to health outcomes in midchildhood in Tanzania. Children who participated in 2 randomized trials of micronutrient supplements in infancy were followed up in midchildhood (4.6-9.8 years of age). Anthropometry was measured at age 6 and 52 weeks in both trials, and blood samples were available from children at 6 weeks and 6 months from 1 trial. Linear regression was used for height-for-age z-score, body mass index-for-age z-score, and weight for age z-score, and blood pressure analyses; log-binomial models were used to estimate risk of overweight, obesity, and stunting in midchildhood. One hundred thirteen children were followed-up. Length-for-age z-score at 6 weeks and delta length-for-age z-score from 6 to 52 weeks were associated independently and positively with height-for-age z-score and inversely associated with stunting in midchildhood. Delta weight-for-length and weight-for-age z-score were also positively associated with midchildhood height-for-age z-score. The 6-week and delta weight-for-length z-scores were associated independently and positively with midchildhood body mass index-for-age z-score and overweight, as was the...Continue Reading

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May 28, 2019·The American Journal of Clinical Nutrition·Stephanie A RichardUNKNOWN MAL-ED Network Investigators
Dec 10, 2020·Archives of public health = Archives belges de santé publique·Frederick Inkum DanquahDesmond Kuupiel

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
biopsies

Clinical Trials Mentioned

NCT00197730
NCT00421668

Software Mentioned

Access
SAS

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