Infarct rim: effect of hyperglycemia on direct current potential and [14C]2-deoxyglucose phosphorylation

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
M Nedergaard, J Astrup

Abstract

Focal ischemia was produced by occlusion of the right middle cerebral artery (MCA) in normo- and hyperglycemic rats. In the cortical infarct rim, regional [14C]2-deoxyglucose [( 14C]2-DG) phosphorylation was correlated to spontaneous transient changes in extracellular potassium recorded as direct current (DC) potential deflections. In normoglycemic rats the DC potential showed transient but recurrent deflections in the first hours following MCA occlusion. The 2-DG phosphorylation was elevated by 200% in the same area. In contrast, hyperglycemic rats had no, or a single, deflection of the DC potential in the rim, and the 2-DG phosphorylation remained normal. The same pattern was obtained by application of 3 M KCl to the exposed cortex. In normoglycemia potassium application resulted in recurrent deflections of the DC potential, and 2-DG phosphorylation increased in most parts of the hemisphere. Hyperglycemic animals had a nearly stable DC potential, and 2-DG phosphorylation increased only in the tissue area situated directly below the site of potassium application. The results indicate that metabolism in the cortical infarct rim is stimulated by spontaneous and recurrent changes in extracellular potassium--a phenomenon that may ...Continue Reading

References

Aug 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M NedergaardN H Diemer
Jan 1, 1986·Acta Psychiatrica Scandinavica·J CuttingR Jenkins
Jan 1, 1970·Journal of Neurobiology·A Van Harreveld, E Fifková
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A J StrongJ A Hardy
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A J StrongG Gibson
Oct 1, 1981·Journal of Neurochemistry·A GjeddeB Quistorff
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R J HarrisM Bayhan
Jan 1, 1957·Pflügers Archiv : European journal of physiology·J BURES, O BURESOVA
May 1, 1960·Journal of Neurophysiology·J BURES, O BURESOVA
Aug 1, 1951·Electroencephalography and Clinical Neurophysiology·A A P LEAO

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Citations

Aug 1, 1990·Annals of Neurology·H Hattori, C G Wasterlain
Oct 1, 1994·Annals of Neurology·K A Hossmann
Sep 25, 2004·Glia·Alexander BondarenkoMitchell Chesler
Apr 15, 1995·Journal of Neuroscience Research·S M MassaF R Sharp
Mar 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M L GyngellK A Hossmann
Dec 1, 1995·Journal of Neurobiology·M NedergaardS A Goldman
Dec 1, 1989·Metabolic Brain Disease·K E PeekJ Labove
May 20, 2006·Cellular and Molecular Neurobiology·Konstantin-Alexander Hossmann
May 24, 1988·Brain Research·M Nedergaard, A J Hansen
Feb 29, 1992·Lancet·W Pulsinelli
Oct 24, 1994·Neuroscience Letters·U AdénB B Fredholm
Apr 20, 1999·Computers in Biology and Medicine·E RuppinS Goodall
Mar 1, 1997·Neuroscience and Biobehavioral Reviews·B H Juurlink, M I Sweeney
Mar 1, 1997·Neuroscience and Biobehavioral Reviews·W Walz
Dec 26, 2001·Brain Research. Brain Research Reviews·A Gorji
Apr 7, 2000·Brain Research. Brain Research Reviews·H Martins-FerreiraC Nicholson
Sep 1, 1995·Trends in Pharmacological Sciences·C P Taylor, B S Meldrum
May 1, 2007·Nature Neuroscience·Takahiro TakanoMaiken Nedergaard
Aug 8, 2001·The European Journal of Neuroscience·A ArvidssonO Lindvall
Mar 4, 2000·Clinical and Experimental Pharmacology & Physiology·F el-SabbanH L Edmonds
Mar 29, 2002·Clinical and Experimental Pharmacology & Physiology·Thanh G PhanGeoffrey A Donnan
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·V I Koroleva, J Bures

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