PMID: 9535449Apr 16, 1998Paper

Infarct size and location determine development of mitral regurgitation in the sheep model

The Journal of Thoracic and Cardiovascular Surgery
Joseph H GormanL H Edmunds

Abstract

This study tests the hypothesis that neither small nor large myocardial infarctions that include the anterior papillary muscle produce mitral regurgitation in sheep. Coronary arterial anatomy to the anterior left ventricle and papillary muscle was determined by dye injection in 41 sheep hearts and by triphenyl tetrazolium chloride in 13. Development of acute or chronic mitral regurgitation and changes in left ventricular dimensions were studied by use of transdiaphragmatic echocardiography in 21 sheep after infarction of 24% and 33% of the anterior left ventricular mass. These data were compared with previous data from large and small posterior left ventricular infarctions. Ligation of two diagonal arteries infarcts 24% of the left ventricular mass and 82% of the anterior papillary muscle. Ligation of both diagonals and the first circumflex branch infarcts 33% of the left ventricle and all of the anterior papillary muscle. Neither infarction causes mitral regurgitation, although left ventricular cavity dimensions increase significantly at end systole. After the smaller infarction, the left ventricular cavity enlarges 150% over 8 weeks without mitral regurgitation. In sheep small and large infarctions of the anterior wall that i...Continue Reading

References

Dec 1, 1989·The Annals of Thoracic Surgery·L J MarkovitzL H Edmunds
Aug 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·M De Brabander, W Schaper
Apr 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·R C GormanL H Edmunds
Jan 1, 1995·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·L H CohnS F Aranki
Mar 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·J R GlassonD C Miller
Nov 14, 1997·The Annals of Thoracic Surgery·J H GormanL H Edmunds

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Citations

May 3, 2013·Annals of Biomedical Engineering·Manuel K RauschEllen Kuhl
Mar 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Frederick A TibayanD Craig Miller
Mar 5, 2005·The Journal of Thoracic and Cardiovascular Surgery·Yoshiharu EnomotoRobert C Gorman
Sep 20, 2002·The Annals of Thoracic Surgery·Sina L MoainieRobert C Gorman
Nov 19, 2002·Coronary Artery Disease·Yochai BirnbaumBarry F Uretsky
Jan 27, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Wei YinDanny Bluestein
Oct 8, 2009·Circulation. Heart Failure·Jennifer A Dixon, Francis G Spinale
Jan 25, 2002·Seminars in Thoracic and Cardiovascular Surgery·A W StanleyUNKNOWN RESTORE Group
Feb 19, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·David Andrew SidebothamTrevor Fayers
Jan 23, 2016·Journal of the American College of Cardiology·Jacob P Dal-BiancoUNKNOWN Leducq Transatlantic Mitral Network
Oct 21, 2015·Nature Reviews. Cardiology·Robert A LevineUNKNOWN Leducq Mitral Transatlantic Network
Jan 29, 2005·The Journal of Thoracic and Cardiovascular Surgery·Joseph C WalkerMark B Ratcliffe
May 14, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Min PuWilliam R Davidson
Apr 1, 2004·The Surgical Clinics of North America·Robert C GormanJoseph H Gorman
Mar 22, 2008·The Annals of Thoracic Surgery·Sandro GelsominoGian Franco Gensini
Nov 29, 2007·Journal of Interventional Cardiology·Nicolo Piazza, Raoul Bonan
Jan 29, 2008·Journal of the American College of Cardiology·Ronen BeeriRobert A Levine
Jan 29, 2008·Journal of the American College of Cardiology·Maurice Enriquez-SaranoDaniel Burkhoff
Mar 12, 2004·Journal of the American College of Cardiology·T Sloane GuyRobert C Gorman
Jun 5, 2008·Journal of cardiology·Yutaka OtsujiChuwa Tei
Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·Marco CirilloEugenio Quaini
Nov 1, 2012·The Journal of Thoracic and Cardiovascular Surgery·Andrew W SiefertAjit P Yoganathan
Jun 9, 2005·The Journal of Thoracic and Cardiovascular Surgery·Frederick A TibayanD Craig Miller
Oct 13, 2016·Circulation. Cardiovascular Interventions·Christopher B RodellRobert C Gorman
May 19, 2012·Circulation Research·Steven R HouserUNKNOWN American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Function
Sep 30, 2009·Circulation·Mitesh V BadiwalaVivek Rao
Oct 22, 2009·The International Journal of Artificial Organs·Jef H GeensBart P Meyns
Nov 16, 2017·Annals of Biomedical Engineering·Manuel K RauschTomasz A Timek
Sep 26, 2019·Frontiers in Cardiovascular Medicine·Joseph S Piktel, Lance D Wilson
Jan 9, 2021·Frontiers in Cardiovascular Medicine·Harish SharmaRichard P Steeds

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