Infarct size estimated from serial serum creatine phosphokinase in relation to left ventricular hemodynamics

Circulation
W BleifeldS Effert

Abstract

In 50 patients with proven acute myocardial infarction (AMI), left ventricular hemodynamics (pulmonary end-diastolic pressure [PAEDP]; cardiac index [CI]; stroke volume index [SVI]; and SVI/PAEDP were related to the size of the acute infarct. Acute infarct mass was calculated from serial determinations of serum creatine phosphokinase (CPK) every two hours, using a computer program. In 15 cases postmortem measurement of acute infarct size after staining with Nitro-BT was made and correlated with calculated infarct size. Correlation in this limited number of cases was good with a mean difference of 7 g. Acute infarct mass in 38 survivors was 46 +/- 5 g and was significantly smaller (P less than 0.05) than in the 12 nonsurvivors (76 +/- 12 g.) PAEDP in surviving patients was significantly lower (17 +/- 1 mm Hg) and SVI (36 ml/m2) and SVI/PAEDP (2.4 ml/m2/mm Hg) significantly higher than in the nonsurvivors (PAEDP: 24 mm Hg; SVI: 23 ml/m2; SVI/PAEDP: 0.86 ml/m2/mm Hg) (P less than 0.001 for all differences). Similar significant differences were observed between patients not in shock and those in cardiogenic shock. Although in 39 patients, in whom the infarction was their first, infarct mass was larger (58 +/- 6 g) than in 11 patien...Continue Reading

References

Sep 8, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·J P ChapelleH E Kulbertus
Mar 14, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·P GrandeK Alstrup
May 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·W T HermensA van der Laarse
Feb 1, 1979·Computers and Biomedical Research, an International Journal·B P MurphyP L Thompson
Jan 5, 2002·Journal of the American College of Cardiology·Stefano SavonittoGUSTO-IIb Investigators
Jun 1, 1983·Journal of the American College of Cardiology·G S HirsowitzS Goldstein
Jan 5, 1984·The New England Journal of Medicine·International Collaborative Study Group
Jul 26, 1984·The New England Journal of Medicine·R RobertsW K Poole
Jun 1, 1979·British Journal of Clinical Pharmacology·D Maclean
Feb 1, 1979·Australian and New Zealand Journal of Medicine·P L Thompson
Aug 12, 1978·British Medical Journal·P L Thompson, J S Robinson
Sep 1, 1979·British Heart Journal·S YusufP Sleight
May 1, 1981·British Heart Journal·J H JürgensenO Pedersen-Bjergaard
Dec 1, 1983·British Heart Journal·J HerlitzA Waldenström
Feb 1, 1988·British Heart Journal·C de ZwaanW T Hermens
Jun 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·J A KragtenM P van Dieijen-Visser
Mar 15, 1997·The American Journal of Cardiology·A MehtaM Billie
Jul 16, 2014·Archivos de cardiología de México·Maximiliano de AbreuCarlos Tajer
Apr 1, 1978·The Journal of Clinical Investigation·S F VatnerP R Maroko
Jun 1, 1982·Critical Reviews in Clinical Laboratory Sciences·R Bais, J B Edwards
Sep 22, 2010·European Journal of Clinical Investigation·Annemieke Van DijkHans W M Niessen
Jun 27, 1983·The American Journal of Medicine·R Roberts
Jul 1, 1980·The American Journal of Cardiology·D C WarltierH L Brooks
Mar 31, 1976·The American Journal of Cardiology·B E SobelK B Larson

Related Concepts

Computer Software
Myocardial Contraction
Lung
Macro-Creatine Kinase
Left Ventricular Structure
Autopsy
Diastolic Blood Pressure
Myocardial Infarction
Acute Disease
Cardiac Catheterization Procedures

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