Infarction of the Splenium of the Corpus Callosum in the Age of COVID-19: A Snapshot in Time

Stroke; a Journal of Cerebral Circulation
Steven A Sparr, Phyllis L Bieri

Abstract

Ischemic infarction of the corpus callosum is rare and infarction isolated to the corpus callosum alone rarer still, accounting for much <1% of ischemic stroke in most stroke registries. About half of callosal infarctions affect the splenium. During a 2-week period, at the height of the coronavirus disease 2019 (COVID-19) pandemic in New York City, 4 patients at Montefiore Medical Center in the Bronx were found to have ischemic lesions of the splenium of the corpus callosum, 2 with infarction isolated to the corpus callosum. All patients tested positive for COVID-19 and 3 had prolonged periods of intubation. All had cardiovascular risk factors. Clinically, all presented with encephalopathy and had evidence of coagulopathy and raised inflammatory markers. Infarction of the splenium of the corpus callosum is exceedingly rare and a cluster of such cases suggests COVID-19 as an inciting agent, with the mechanisms to be elucidated.

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Citations

Dec 1, 2020·Frontiers in Neurology·Pedro FraimanMarialuisa Zedde
Oct 30, 2020·European Journal of Physical and Rehabilitation Medicine·Elisa AndrenelliUNKNOWN International Multiprofessional Steering Committee of Cochrane Rehabilitation REH-COVER action
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Dec 29, 2020·Frontiers in Cell and Developmental Biology·Shijia Yu, Mingjun Yu
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Mar 27, 2021·The Neuroradiology Journal·John C BensonDavid F Kallmes

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