Infected chronic wounds show different local and systemic arginine conversion compared with acute wounds

The Journal of Surgical Research
Iris B J G DebatsRene R W J van der Hulst

Abstract

Several experimental studies have shown the importance of arginine in wound healing. However, little is known about its role in human wound healing. In this study, we investigated arginine metabolism in impaired wound healing. Twenty patients with chronic wounds and 10 patients with acute wounds were included in a prospective study. Amino acids, nitrate/nitrite, and arginase concentrations were determined in plasma and wound fluid using high-performance liquid chromatography and enzyme-linked immunosorbent assay. Chronic wounds were divided into two groups: noninfected chronic wounds (n = 11) and infected chronic wounds (n = 9), based on quantitative bacterial analysis of wound fluid samples. Plasma arginine levels, next to total plasma amino acid levels, were significantly decreased in patients with infected chronic wounds compared with patients having acute or noninfected wounds. Citrulline and ornithine levels were significantly increased in infected chronic wounds and related to decreased nitrate/nitrite levels, whereas wound fluid arginine levels were similar in all groups. In addition, wound fluid arginase levels of infected chronic wounds were significantly enhanced. This study demonstrates that patients with infected ch...Continue Reading

References

Jan 1, 1980·Annual Review of Biochemistry·E Adams, L Frank
Jan 1, 1982·Surgery·D W Fitzpatrick, H Fisher
Nov 1, 1980·Archives of Dermatology·J Lesiewicz, L A Goldsmith
Sep 15, 1995·Annals of Internal Medicine·D M Smith
Jul 1, 1993·The Journal of Surgical Research·J E AlbinaB Mastrofrancesco
Apr 1, 1993·Journal of the American Geriatrics Society·R A BreslowA P Goldberg
Jun 1, 1996·The Journal of Surgical Research·M R SchafferA Barbul
Apr 16, 1998·The Journal of Clinical Investigation·K YamasakiT R Billiar
May 16, 1998·Nutrition·P R RobertsG P Zaloga
Jun 10, 1998·Biochemical and Biophysical Research Communications·F J ThorntonA Barbul
Dec 29, 1999·Diseases of the Colon and Rectum·M ShashidharanM A Christensen
Aug 22, 2000·European Journal of Clinical Nutrition·R J NijveldtP A van Leeuwen
Feb 27, 2001·Annals of Surgery·J B OchoaS M Morris
Sep 21, 2001·European Journal of Gastroenterology & Hepatology·J L UrdialesF Sánchez-Jiménez
Oct 26, 2001·The Journal of Surgical Research·R H LeeA Barbul
Apr 27, 2002·American Journal of Surgery·Maria B Witte, Adrian Barbul
Oct 9, 2002·Molecular Microbiology·Artur SchmidtchenLars Björck
Oct 9, 2002·Advances in Skin & Wound Care·Nancy Collins
Dec 6, 2002·The American Journal of Pathology·Eric MahoneyJorge Albina
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Junghee LeeRajiv R Ratan
May 20, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Han Ping ShiAdrian Barbul
May 27, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jens KondrupUNKNOWN Ad Hoc ESPEN Working Group
Jun 18, 2003·Trends in Immunology·Vincenzo BrontePaola Zanovello
Jul 26, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·R H HouwingJ R Haalboom
Jul 26, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J KondrupUNKNOWN Educational and Clinical Practice Committee, European Society of Parenteral and Enteral Nutrition (ESPEN)
Aug 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hong YuRamaswamy K Iyer
Dec 12, 2003·Molecular Biotechnology·Klaus Maskos, Wolfram Bode
Jan 1, 2004·The Journal of Biological Chemistry·Andrey GalkinOsnat Herzberg
Mar 17, 2004·Current Opinion in Infectious Diseases·Ruth Edwards, Keith G Harding
Oct 1, 2004·Plastic and Reconstructive Surgery·Vishal SaxenaDennis P Orgill
May 14, 2005·Toxicology and Applied Pharmacology·Mustafa CetinerBerrak C Yeğen

❮ Previous
Next ❯

Citations

Dec 19, 2007·Immunobiology·Elisa PeranzoniPaola Zanovello
Feb 20, 2013·The Journal of Pediatrics·Mariëlle P K J EngelenNicolaas E P Deutz
May 27, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E P Deutz
May 29, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jens Martens-LobenhofferStefanie M Bode-Böger
Mar 5, 2017·Applied and Environmental Microbiology·Majken SønderholmThomas Bjarnsholt
Aug 22, 2007·Clinical Science·Marcel C G van de PollCornelis H C Dejong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.