Infected malnourished children displayed changes in early activation and lymphocyte subpopulations

Acta Paediatrica
Oralia Nájera-MedinaMaría Cristina González-Torres

Abstract

Malnutrition and infections cause immunological changes in lymphocyte subpopulations and their functionality. We evaluated the activation capacity of lymphocytes and memory cells in 10 well nourished, seven well-nourished infected and eight malnourished infected children before and after treatment. All the children were patients in Mexico City and were less than three years of age. The expression of various cluster of differentiation (CD) cells was assessed by flow cytometry: CD45RA (naïve) and CD45RO (memory) antigens on CD4 lymphocytes and CD69 in all lymphocytes. Well-nourished infected children showed a higher percentage of activated T lymphocyte (T cells), CD8+ and CD4+ memory cells during the infectious phase, suggesting that the activation mechanisms were triggered by infection. T cells from malnourished infected children showed a lower percentage of activated and memory cells. The T cell population size returned to baseline during the resolution phase of the infection in well-nourished infected children, but their T, B lymphocyte and natural killer (NK) cell counts remained high. In malnourished infected children, activated NK cells counts were low before and after therapy. After therapy, malnourished infected children ...Continue Reading

References

Aug 1, 1997·The American Journal of Clinical Nutrition·R K Chandra
Dec 22, 1999·The Proceedings of the Nutrition Society·R K Chandra
Dec 12, 2001·Clinical and Experimental Immunology·O NájeraR Ortiz
Jan 1, 1956·The Proceedings of the Nutrition Society
May 13, 2004·Clinical and Diagnostic Laboratory Immunology·Oralia NájeraRocío Ortiz
Mar 5, 2005·Trends in Immunology·David SanchoFrancisco Sánchez-Madrid
Mar 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·B M Lesourd, L Mazari
Jul 25, 2006·Immunity·Jodie S HaringJohn T Harty
Nov 30, 2006·Annual Review of Immunology·Matthew A Williams, Michael J Bevan
May 3, 2007·PLoS Medicine·Ulrich E Schaible, Stefan H E Kaufmann
Nov 21, 2007·The British Journal of Nutrition·Wilson SavinoSuse Dayse Silva-Barbosa
Feb 23, 2008·Eastern Mediterranean Health Journal = La Revue De Santé De La Méditerranée Orientale = Al-Majallah Al-ṣiḥḥīyah Li-sharq Al-mutawassiṭ·M F NassarM A El Badawy
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cherrie-Lee SmallZhou Xing
May 23, 2008·Journal of Clinical Immunology·Haydeé González-MartínezMaría Cristina González-Torres
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Berta N VazquezPilar Lauzurica
Mar 25, 2010·Immunology·Megan K L MacLeodPhilippa Marrack
Mar 3, 2011·PloS One·Tamson V MooreAnne I Sperling

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Citations

Aug 17, 2019·Frontiers in Immunology·Claire D BourkeAndrew J Prendergast

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