Infection adjacent to titanium and bone cement implants: an experimental study in rabbits

Biomaterials
L Sanzén, L Linder

Abstract

A pure titanium cylinder or a piece of bone cement was implanted in each upper tibial metaphysis of 20 rabbits. After 4 months radiograms were taken and 10(4), 10(6), or 10(8) Staphylococcus aureus were injected into each leg through central holes in the implants in three groups of animals. Four weeks later new radiograms, bacteriological and histological biopsies were obtained. Three animals died before the end of the experiment. In animals which received 10(6) or 10(8) S. aureus radiographic signs of infection were found in 11/22 legs with both titanium and bone cement implants. No radiolucent zones developed around the implants. Bacteriological cultures from bone close to the implants were negative in all legs with titanium implants and positive in four legs with cement implants. Seven cultures were negative in spite of radiographic changes. It is concluded that after a proper time for wound healing the bone around unloaded implants of both titanium and bone cement is fairly resistant to infection. In some cases, healing of an infection in the surrounding bone seems possible.

References

Mar 1, 1990·Journal of Biomedical Materials Research·P TengvallI Lundström
Apr 1, 1989·Acta Orthopaedica Scandinavica·L Linder

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Citations

Apr 21, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Frederik HahnKan Min
Mar 30, 2007·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Kouichi AdachiHiroyuki Shindo
Nov 6, 2013·Journal of Orthopaedic Surgery and Research·Jim C E OdekerkenTim J M Welting
Jan 1, 2013·Pathogens·David LebeauxChristophe Beloin
Dec 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E SheehanD McCormack
Feb 24, 2001·Journal of Biomedical Materials Research·P Mainil-VarletU Schlegel

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