Infection by discordant strains of HIV-1 markedly enhances the neutralizing antibody response against heterologous virus.

Journal of Virology
Rebecca L R PowellPhillipe N Nyambi

Abstract

High-risk cohorts in East Africa and the United States show rates of dual HIV-1 infection--the concomitant or sequential infection by two HIV-1 strains--of 50% to 100% of those of primary infection, and our normal-risk HIV-positive cohort in Cameroon exhibits a rate of dual infection of 11% per year, signifying that these infections are not exceptional. Little is known regarding the effect of dual infections on host immunity, despite the fact that they provide unique opportunities to investigate how the immune response is affected when challenged with diverse HIV-1 antigens. Using heterologous primary isolates, we have shown here that dual HIV-1 infection by genetically distant strains correlates with significantly increased potency and breadth of the anti-HIV-1 neutralizing antibody response. When the neutralization capacities of sequential plasma obtained before and after the dual infection of 4 subjects were compared to those of matched plasma obtained from 23 singly infected control subjects, a significant increase in the neutralization capacity of the sequential sample was found for 16/28 dually infected plasma/virus pairs, while only 4/159 such combinations for the control subjects exhibited a significant increase (P < 0....Continue Reading

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Mar 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rebecca L R PowellPhillipe N Nyambi

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Citations

Apr 19, 2011·AIDS Research and Human Retroviruses·Per Johan KlasseJohn P Moore
Jan 22, 2011·AIDS·Carl V Hanson
Feb 15, 2013·Journal of Virology·Penny L MooreLynn Morris
Feb 18, 2014·Cell·Anthony P WestMichel C Nussenzweig
Dec 12, 2012·Virology·Marit J van Gils, Rogier W Sanders
Mar 14, 2017·PloS One·Colleen R CourtneyRalf Dürr
Jun 16, 2017·Journal of Virology·Gabriel A WagnerDavey M Smith
Mar 26, 2014·Current Opinion in HIV and AIDS·Cynthia A DerdeynLynn Morris
Feb 26, 2016·AIDS Research and Human Retroviruses·Marion CornelissenAntoinette C van der Kuyl
Sep 7, 2018·Retrovirology·Elise Landais, Penny L Moore
May 21, 2019·Current Opinion in HIV and AIDS·Irene A AbelaAlexandra Trkola
Jun 30, 2019·Virology·Evonne WoodsonEric Hunter

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