Infection Control in Teeth with Apical Periodontitis Using a Triple Antibiotic Solution or Calcium Hydroxide with Chlorhexidine: A Randomized Clinical Trial

Journal of Endodontics
Marcia E F ArrudaIsabela N Rôças

Abstract

This randomized clinical study compared the antibacterial effectiveness of treatment protocols using either a triple antibiotic solution (1 mg/mL) or calcium hydroxide/chlorhexidine paste as interappointment medication in infected canals of teeth with primary apical periodontitis. The root canals of single-rooted teeth with apical periodontitis were prepared by using a reciprocating single-instrument technique with 2.5% sodium hypochlorite irrigation and then medicated for 1 week with either a triple antibiotic solution (minocycline, metronidazole, and ciprofloxacin) at 1 mg/mL (n = 24) or a calcium hydroxide paste in 2% chlorhexidine gluconate (n = 23). Samples were taken from the canal at the baseline (S1), after chemomechanical preparation (S2), and after intracanal medication (S3). DNA extracts from clinical samples were evaluated for total bacterial reduction using a 16S ribosomal RNA gene-based quantitative polymerase chain reaction assay. All S1 samples were positive for the presence of bacteria, and counts were substantially reduced after treatment procedures (P < .01). Bacterial levels in S2 and S3 samples did not significantly differ between groups (P > .05). S2 to S3 reduction was 97% in the antibiotic group and 39% ...Continue Reading

Citations

May 14, 2020·Expert Opinion on Drug Delivery·Maurício G C SousaOctávio L Franco
May 28, 2019·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Ashraf F Fouad
Sep 21, 2020·Journal of Endodontics·Juliana S RibeiroMarco C Bottino
Oct 29, 2020·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·M YoshpeM Ashkenazi
Apr 18, 2021·Journal of Endodontics·Carmen María Ferrer-LuqueMatilde Ruiz-Linares
Oct 13, 2021·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Rodrigo S PereiraFlávio R F Alves

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