Infection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland

The Journal of Hospital Infection
K BurnsF Fitzpatrick

Abstract

Clostridium difficile is an important healthcare-associated pathogen. Hypervirulent strains such as those belonging to ribotype 027 have been widely reported in recent years. A second strain associated with hypervirulence is ribotype 078 and the prevalence of Clostridium difficile infection (CDI) due to this ribotype appears to be increasing. This report describes an outbreak, in which 15cases of CDI due to ribotype 078 were detected in an Irish hospital and from a nursing home in the hospital's catchment area. C. difficile ribotype 078 accounted for 15% of total isolates submitted for ribotyping. The average age of patients with CDI due to ribotype 078 was 76 years. Forty-six percent of patients experienced recurrence of symptoms within eight weeks of diagnosis and CDI was felt to have directly contributed to five of the eight deaths. Use of enhanced DNA fingerprinting identified clusters within the 15 cases and suggested hitherto unrecognised links between some patients with CDI. Such approaches offer the promise to delineate common sources and transmission routes for C. difficile.

References

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Citations

Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Panagiotis PapatheodorouKlaus Aktories
Mar 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Sarah WalkerUNKNOWN Infections in Oxfordshire Research Database
Jul 17, 2012·Applied and Environmental Microbiology·Vincenza RomanoStefano Dumontet
Oct 1, 2011·Journal of Clinical Microbiology·Warren N FawleyUNKNOWN Clostridium difficile Ribotyping Network for England and Northern Ireland
Jun 1, 2011·PloS One·Kate E DingleDerrick W Crook
Sep 6, 2012·The Journal of Hospital Infection·L PattersonB Smyth
Mar 20, 2015·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·D W EyreT V Riley
Nov 26, 2010·Current Opinion in Gastroenterology·Caoilfhionn O'Donoghue, Lorraine Kyne
May 26, 2011·Critical Reviews in Microbiology·Melina Kachrimanidou, Nikolaos Malisiovas
Nov 28, 2013·Current Opinion in Gastroenterology·Nejma AboutalebJaap T van Dissel

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