Infection in a neonate caused by Pichia fabianii: importance of molecular identification

Medical Mycology
H S BhallyWilliam G Merz

Abstract

Pichiafabianii, an uncommon yeast species recovered from clinical specimens, was documented as the cause of an infection in a 5-week-old female twin delivered at 25 and 3/7 weeks. She developed respiratory distress syndrome and necrotizing enterocolitis. At the time of the infection, she was febrile, thrombocytopenic, and still was requiring minimal ventilatory support. Blood cultures drawn on two consecutive days were positive for a germ tube negative yeast. Phenotypic methods including carbohydrate fermentations and assimilations (API 20C AUX) did not identify the yeast. Sequencing of D1/D2 domain of the large subunit rDNA was performed in one laboratory and sequencing a subunit of D2 performed in a second laboratory identified the yeast as P. fabianii. The organism was susceptible in vitro to amphotericin B, fluconazole and 5-fluorocytosinc. The patient responded to amphotericin B and removal of her vascular catheter. This case illustrates that there are an increasing number of fungi that may be pathogenic. Phenotypic tests may fail to identify them, emphasizing the need for commercially available, molecular based assays for identification.

References

May 1, 1990·The Journal of Infectious Diseases·D P DooleyB S Jeffery
Dec 1, 1994·Journal of Clinical Microbiology·D P DooleyB S Jeffrey
Aug 1, 1993·Journal of Paediatrics and Child Health·M P Dyke, K Ott
Apr 20, 2002·Current Opinion in Infectious Diseases·S M Hudome, M C Fisher
Sep 2, 2003·Pediatrics·Daniel K BenjaminReese H Clark

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Citations

Aug 13, 2010·Applied Microbiology and Biotechnology·Sabine Gognies, Abdel Belarbi
Apr 19, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C I MonteroP R Murray
Aug 19, 2007·Journal of Clinical Microbiology·A AdlerI Polacheck
Mar 21, 2013·BMC Research Notes·Yuan WuYing Cheng
Jun 16, 2011·Medical Mycology·Frederic GabrielIsabelle Accoceberry
Nov 26, 2015·Journal de mycologie médicale·A N AtreM S Modak
Feb 9, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Nobuchika HasejimaHidekazu Matsushima
Oct 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C ArendrupUNKNOWN European Confederation of Medical Mycology
Dec 1, 2015·Case Reports in Infectious Diseases·Jonathan BaghdadiTheodoros Kelesidis
Aug 9, 2016·Medical Mycology·Mario Fernández-RuizUNKNOWN GEIH-GEMICOMED (SEIMC) and REIPI
Jul 22, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yaovi HoladeK Boniface Kokoh
Mar 12, 2013·Journal of Medical Microbiology·Jae Won YunNam Yong Lee
Jul 16, 2015·Critical Reviews in Biotechnology·Tuomas MehtiöAnu Koivula
Jul 25, 2021·Revista iberoamericana de micología·Eduardo Álvarez Duarte, Nicolás Cepeda

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