Infection in diabetic osteoarthropathy: use of indium-labeled leukocytes for diagnosis

Radiology
A H MaurerL S Malmud

Abstract

Indium-111 labeled leukocyte imaging was compared with three-phase skeletal scintigraphy as a means of determining whether osteomyelitis was complicating diabetic osteoarthropathy. Three-phase scintigraphy demonstrated increased activity in both infected and noninfected osteopathic bone, with a sensitivity of 75% and a specificity of 56% for osteomyelitis. Leukocyte imaging had the same sensitivity but was most helpful for excluding infection (specificity, 89%) when three-phase imaging could not. Abnormal leukocyte localization was seen at the primary site of infection in all cases within 4 hours after injection. Disadvantages of leukocyte imaging included long preparation time, low count rates resulting in poor spatial resolution, and absence of bone landmarks, which made it difficult to differentiate soft tissue from bone infection.

Citations

Mar 1, 1996·Clinical Nuclear Medicine·A KolindouB D Collier
Sep 1, 1995·European Journal of Nuclear Medicine·A H ElgazzarH R Maxon
Sep 14, 2006·Nuclear Medicine Communications·Gabriela CapriottiAlberto Signore
Jan 24, 2016·The Foot·Javier La FontaineEdward Jude
Aug 5, 2010·Foot and Ankle Clinics·Daniel J Cuttica, Terrence M Philbin
Jul 7, 2007·Clinics in Podiatric Medicine and Surgery·Rebecca A LoredoSamir Chhaya
Oct 1, 1988·Seminars in Nuclear Medicine·N C Gupta, J A Prezio
Oct 6, 1997·Surgery·M D KersteinA B Roberts
Nov 19, 1997·Seminars in Nuclear Medicine·C J Palestro, M A Torres
Nov 29, 2008·Seminars in Nuclear Medicine·Christopher J Palestro, Charito Love
Dec 5, 2002·Radiologic Clinics of North America·William B Morrison, Hans Peter Ledermann
Nov 26, 2003·Clinics in Podiatric Medicine and Surgery·Enzo J Sella, Dawn M Grosser
Apr 1, 1988·Seminars in Nuclear Medicine·H N WellmanW N Capello
Aug 1, 1991·American Journal of Surgery·J R DurhamW L Smead
Nov 12, 2016·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Kush Kumar
Jun 3, 2009·Foot & Ankle International·Enzo J Sella
Oct 23, 2010·Foot & Ankle Specialist·Rebecca LoredoDarlene Metter
Jul 8, 1999·Foot & Ankle International·P R JayT Le
Sep 5, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ting-Heng Chou, Mitchel R Stacy
Nov 2, 2019·Health Technology Assessment : HTA·Alexis LlewellynMark Simmonds
Jun 12, 2020·Journal of Clinical Medicine·Chiara LauriLuigi Uccioli

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