Infection is the chief cause of mortality and non-death censored graft loss in the first year after renal transplantation in a resource limited population: A single centre study

Nephrology
Vikraman GopalakrishnanSoumita Bagchi

Abstract

Few studies have assessed the impact of infections after renal transplantation (RTX) in low and middle income countries. This single centre study aimed to delineate the profile and impact of infections requiring hospitalization (IRH) occurring in the first year after RTX in India. Patients who underwent RTX between July 2012 and June 2015 were followed up for 12 months after transplantation. 60.2% of the 387 patients studied had at least one IRH and total 492 infections were diagnosed. The most common were urinary tract (30.3%), gastrointestinal (17.1%) and pulmonary (11.2%) infections. Viral aetiology (33.3%) was most frequent, followed by bacterial (23.6%), parasitic (5.1%), tuberculosis (4.5%), and fungal infections (3.9%). 86.4% deaths were due to infections. One year patient and graft survival were inferior among recipients with IRH compared to those with no IRH: 91.8% vs. 98.1% (log rank = 0.010) and 90.1% vs. 97.4% (log rank = 0.006) respectively. Average monthly income per family member <5000 Rupees (75 USD), NODAT, and acute rejection were independent risk factors for IRH. The profile of IRH is unique involving opportunistic, community-acquired and endemic infections seen in this country. It is the predominant cause of...Continue Reading

References

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Oct 25, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sanjay K AgarwalSoumita Bagchi

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Citations

Jul 22, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Katie KorneffelJorge Ortiz
May 8, 2020·Oxidative Medicine and Cellular Longevity·Yang LiuYanfeng Wang
Jan 11, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Shreepriya MangalgiSoumita Bagchi

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