Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: role of CD4+ T cells in controlling larval development.

Infection and Immunity
K M Al-QaoudAchim Hoerauf

Abstract

Litomosoides sigmodontis is the only filaria which develops from infective larvae into adults in immunocompetent laboratory mice. Depletion of CD4+ T cells from infected BALB/c mice resulted in worm and microfilarial burdens significantly higher than those of infected controls. Th2 cytokines, eosinophilia, and immunoglobulin E, which were strongly induced in infected controls, were diminished in CD4-depleted mice.

References

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Citations

Sep 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wiebke HartmannMinka Breloer
Oct 12, 2013·Parasite Immunology·K GentilA Hoerauf
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simone KortenAchim Hoerauf
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric R HouptWilliam A Petri
Oct 27, 2004·Infection and Immunity·Sabine SpechtAchim Hoerauf
Nov 26, 2003·Infection and Immunity·Michael SaeftelAchim Hoerauf
Aug 26, 2006·Tropical Medicine & International Health : TM & IH·S MandA Hoerauf
Jul 5, 2013·Clinical Microbiology Reviews·C Paul MorrisEdward Mitre
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bhargavi RajanThiruchandurai V Rajan
Sep 24, 2005·Parasite Immunology·A HoeraufS Specht
Nov 18, 2015·Bioorganic & Medicinal Chemistry Letters·Daniel GlobischKim D Janda
Mar 18, 2006·Filaria Journal·Ramakrishna U Rao, Thomas R Klei

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