PMID: 9525646Apr 3, 1998Paper

Infection of human B lymphocytes with lymphocryptoviruses related to Epstein-Barr virus

Journal of Virology
A MoghaddamFred Wang

Abstract

Lymphocryptoviruses (LCVs) naturally infecting Old World nonhuman primates are closely related to the human LCV, Epstein-Barr virus (EBV), and share similar genome organization and sequences, biologic properties, epidemiology, and pathogenesis. LCVs can efficiently immortalize B lymphocytes from the autologous species, but the ability of a given LCV to immortalize B cells from other Old World primate species is variable. We found that LCV from rhesus monkeys did not immortalize human B cells, and EBV did not immortalize rhesus monkey B cells. In this study, baboon LCV could not immortalize human peripheral blood B cells but could readily immortalize rhesus monkey B cells. Thus, efficient LCV-induced B-cell immortalization across distant Old World primate species appears to be restricted by a species-specific block. To further characterize this species restriction, we first cloned the rhesus monkey LCV major membrane glycoprotein and discovered that the binding epitope for the EBV receptor, CD21, was highly conserved. Stable infections of human B cells with recombinant amplicons packaged in rhesus monkey or baboon LCV envelopes were also consistent with a species-restricted block occurring after virus binding and penetration. Tr...Continue Reading

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Citations

Jan 23, 1999·Current Opinion in Hematology·D E Mosier
Apr 6, 2004·Journal of Medical Primatology·Kamol SakulwiraYong Poovorawan
Mar 12, 2010·Journal of Virology·Kasandra J-L RileyJoan A Steitz
Mar 8, 2008·ILAR Journal·Silke V HausteinStuart J Knechtle
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F WangY Cho
Jun 19, 2015·Journal of Virology·Janine Mühe, Fred Wang
Jun 21, 2002·The Journal of General Virology·Hal B JensonMichael Mackett
Jan 19, 2012·PloS One·Kristine M SmithNina Marano
Jun 26, 2021·Frontiers in Immunology·Cong SunMu-Sheng Zeng

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