Infection of human oral epithelia with Candida species induces cytokine expression correlated to the degree of virulence

The Journal of Investigative Dermatology
Martin SchallerHans C Korting

Abstract

A defined and balanced immunomodulatory response is crucial for the protection of mucosal surfaces being in contact with pathogenic microorganisms. This study examined the local host response mechanisms of epithelial cells in experimental Candida albicans, C. tropicalis, and C. glabrata infections by measuring the expression of cytokines at the mRNA and protein level. During the course of infection with active but not with heat-killed C. albicans stimulation of the gene expression levels for interleukin-1alpha, interleukin-1beta, tumor necrosis factor, Exodus-2, P-selectin ligand, granulocyte-monocyte colony-stimulating factor, and interleukin-8 was observed by standard and quantitative reverse transcription-polymerase chain reaction. This cytokine pattern may favor a chemotactic and a T helper 1 response. Initial moderate or weak upregulation of these cytokine genes by reverse transcription-polymerase chain reaction was also observed in epithelial infection with the less virulent species C. tropicalis and C. glabrata. Heat-killed C. albicans failed to induce an epithelial immune response. At the protein level, expression of interleukin-8 protein was strongly enhanced during the course of C. albicans infection, whereas lower le...Continue Reading

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Apr 14, 2017

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Citations

May 10, 2007·Nature Protocols·Anna Dongari-Bagtzoglou, Helena Kashleva
Apr 5, 2007·Nature Protocols·Martin SchallerBernhard Hube
Nov 10, 2007·The Journal of Clinical Investigation·Günther WeindlMartin Schaller
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