PMID: 8947298Nov 20, 1996Paper

Infection of human T lymphoid cells by human herpesvirus 6 is blocked by two unrelated protein tyrosine kinase inhibitors, biochanin A and herbimycin

AIDS Research and Human Retroviruses
M CironeA Faggioni

Abstract

Human herpesvirus 6 is a T lymphotropic herpesvirus that causes exanthem subitum in infants and is considered a potential cofactor in AIDS etiopathogenesis and progression owing to its in vivo and in vitro interactions with human immunodeficiency virus. We report that no differences in phosphorylation on tyrosine residues of cellular proteins were detectable at early times following HHV-6 infection in comparison to uninfected cells. On the contrary, several cellular proteins appeared phosphorylated on tyrosine at 24-48 hr postinfection. In addition, when tyrosine phosphorylation induced by HHV-6 infection was inhibited by the tyrosine kinase inhibitor biochanin A, the infection of HSB-2 cells was also coordinately reduced, as judged by inhibition of cytopathic effect and by inhibition of early and late viral antigen expression. Similar results were obtained with a second unrelated tyrosine kinase inhibitor, herbimycin. The inhibitors seem to act at a late stage of the viral infectious cycle, since neither viral binding nor internalization were affected. Thus, our results indicate that HHV-6 infection leads to the phosphorylation of protein tyrosine kinases, which may play a role in the course of viral infection, probably by par...Continue Reading

References

Jan 1, 1992·Advances in Virus Research·P E PellettM Yamamoto
Dec 1, 1992·AIDS Research and Human Retroviruses·M CironeA Faggioni
Mar 15, 1990·International Journal of Cancer. Journal International Du Cancer·M CironeA Faggioni
Oct 1, 1990·The Journal of Infectious Diseases·L S WyattN Frenkel
May 1, 1988·The Journal of Experimental Medicine·P LussoR C Gallo
Jun 1, 1993·Trends in Biochemical Sciences·T Mustelin, P Burn
Feb 1, 1995·Immunology Today·P Lusso, R C Gallo
Dec 7, 1994·Journal of the National Cancer Institute·M YadavD V Ablashi

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Citations

Jan 17, 2009·Cell Division·Adam J Hume, Robert F Kalejta
Jun 6, 2007·Future Oncology·Jan H J MartinPaul N Nelson
Aug 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rachel Kolodny, Nathan Linial
Jul 30, 2019·Frontiers in Pharmacology·Chen YuYang Wang
Nov 11, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guixing RenYang Yao

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